Pets in the home and the development of pet allergy in adulthood. The Copenhagen Allergy Study
Pets in the home and the development of pet allergy in adulthood. The Copenhagen Allergy Study
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DOI：
10.1034/j.1398-9995.2003.23639.x
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发表时间：
2003-01-01
期刊：
影响因子：
12.4
通讯作者：
Jorgensen, T
中科院分区：
文献类型：
--
作者：
Linneberg, A;Nielsen, NH;Jorgensen, T
背景资料：这项研究的目的是调查暴露于猫和狗在家里和发展（发病率）的IgE致敏猫和dog.Methods：参与者在1990年以人口为基础的研究15-69岁的人在1998年被邀请到一个后续的关联。在734例受试者（参与率69.0%）中，间隔8年，对常见吸入性过敏原的血清IgE抗体进行了两次评估。关于当前或以前保持的猫和狗在家里的信息是在一份问卷中获得的baseline.Results：猫在家里目前是显着相关的发展IgE sentisization猫（调整后的比值比8.4，95%置信区间（CI）1.7-42.7）。此外，在基线时，对猫以外的过敏原的IgE致敏性方面的特应性倾向是对猫的IgE致敏性发展的独立风险因素。家中的狗与对狗的IgE致敏性发展没有显著相关性。在这个成年人群中，在家中接触猫会增加对猫过敏的风险。在这个问题上需要更多的前瞻性数据。
Background: The aim of the study was to investigate the association between exposure to cat and dog in the home and the development (incidence) of IgE sensitization to cat and dog.Methods: Participants in a population-based study of 15-69-year-olds in 1990 were invited to a follow-up in 1998. Serum IgE antibodies against common inhalant allergens was assessed in 734 subjects (participation rate 69.0%) on two occasions 8 years apart. Information about current or previous keeping of cats and dogs in the home was obtained in a questionnaire at baseline.Results: A cat in the home currently was significantly associated with the development of IgE sentisization to cat (adjusted odds ratio 8.4, 95% confidence interval (CI) 1.7-42.7). Moreover, an atopic predisposition in terms of IgE sensitization to allergens other than cat at baseline was an independent risk factor for the development of IgE sensitization to cat. A dog in the home was not significantly associated with the development of IgE sensitization to dog.Conclusions: In this adult population, exposure to a cat in the home increased the risk of developing IgE sensitization to cat. More prospective data are needed on this issue.