Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
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DOI：
10.1016/j.stem.2015.01.004
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发表时间：
2015-02-05
期刊：
影响因子：
23.9
通讯作者：
Tabar, Viviane
中科院分区：
文献类型：
--
作者：
Piao, Jinghua;Major, Tamara;Auyeung, Gordon;Policarpio, Edelweiss;Menon, Jayanthi;Droms, Leif;Gutin, Philip;Uryu, Kunihiro;Tchieu, Jason;Soulet, Denis;Tabar, Viviane
脑部放射治疗是治疗许多癌症的有力工具，但它与显著和不可逆的长期副作用有关，包括认知能力下降和运动协调障碍。少突胶质祖细胞的耗竭和脱髓鞘是主要的病理特征，在年轻个体中特别明显，并严重限制了治疗选择。在这里，我们测试了人类胚胎干细胞衍生的少突胶质细胞是否可以使用大鼠模型功能性地使受照射的大脑髓鞘再生。我们证明了人少突胶质细胞祖细胞的有效衍生和前瞻性分离，其在移植后，在整个主要的白色物质域迁移，导致结构和功能修复。行为测试显示认知功能完全恢复，而运动缺陷的额外恢复需要伴随移植到小脑中。修复辐射引起的大脑损伤的能力可以显着改善癌症幸存者的前景，并使放射疗法更有效地使用，特别是在儿童中。
Radiation therapy to the brain is a powerful tool in the management of many cancers, but it is associated with significant and irreversible long-term side effects, including cognitive decline and impairment of motor coordination. Depletion of oligodendrocyte progenitors and demyelination are major pathological features that are particularly pronounced in younger individuals and severely limit therapeutic options. Here we tested whether human ESC-derived oligodendrocytes can functionally remyelinate the irradiated brain using a rat model. We demonstrate the efficient derivation and prospective isolation of human oligodendrocyte progenitors, which, upon transplantation, migrate throughout the major white matter tracts resulting in both structural and functional repair. Behavioral testing showed complete recovery of cognitive function while additional recovery from motor deficits required concomitant transplantation into the cerebellum. The ability to repair radiation-induced damage to the brain could dramatically improve the outlook for cancer survivors and enable more effective use of radiation therapies, especially in children.
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影响因子：
3.3
作者：
Acharya MM;Christie LA;Hazel TG;Johe KK;Limoli CL
通讯作者：
Limoli CL
影响因子：
1.9
作者：
OI S;KOKUNAL T;RAIMONDI A J
通讯作者：
RAIMONDI A J
DOI：
10.1158/1078-0432.ccr-11-2903
发表时间：
2013-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Greene-Schloesser D;Moore E;Robbins ME
通讯作者：
Robbins ME
影响因子：
4.7
作者：
Greene-Schloesser D;Robbins ME;Peiffer AM;Shaw EG;Wheeler KT;Chan MD
通讯作者：
Chan MD
影响因子：
5.9
作者：
Douvaras, Panagiotis;Wang, Jing;Zimmer, Matthew;Hanchuk, Stephanie;O'Bara, Melanie A.;Sadiq, Saud;Sim, Fraser J.;Goldman, James;Fossati, Valentina
通讯作者：
Fossati, Valentina