Complexities of Crumbs Function and Regulation in Tissue Morphogenesis
Complexities of Crumbs Function and Regulation in Tissue Morphogenesis
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DOI：
10.1016/j.cub.2013.03.001
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发表时间：
2013-04
期刊：
影响因子：
9.2
通讯作者：
S. Pocha;E. Knust
中科院分区：
文献类型：
--
作者：
S. Pocha;E. Knust
在发育和成人组织动态平衡过程中，建立和维持上皮极性是至关重要的。由进化上保守的蛋白质组成的复杂网络调节这种区隔。Crumbs就是这样的一种蛋白质，它是一种I型跨膜蛋白，最初被证明是果蝇顶端的重要决定因素。我们讨论了最近的研究，这些研究提高了我们对面包屑的功能和调节的理解。在苍蝇和鱼类中获得的新发现，报告了胞外结构域和逆转录-介导的循环的同型相互作用，揭示了对面包屑水平和活性的调节。这些结果--在不同的生物体、组织和发育阶段中获得--表明了比之前假设的更复杂的功能和调控。
Establishing and maintaining epithelial polarity is crucial during development and for adult tissue homeostasis. A complex network of evolutionarily conserved proteins regulates this compartmentalization. One such protein is Crumbs, a type I transmembrane protein initially shown to be an important apical determinant inDrosophila. We discuss recent studies that have advanced our understanding of the function and regulation of Crumbs. New findings obtained in flies and fish, reporting homotypic interactions of the extracellular domain and retromer-mediated recycling, shed light on the regulation of Crumbs levels and activity. These results — obtained in different organisms, tissues and developmental stages — point to more complex functions and regulation than previously assumed.