Increase in tibialis anterior motor cortex excitability following repetitive electrical stimulation of the common peroneal nerve
Increase in tibialis anterior motor cortex excitability following repetitive electrical stimulation of the common peroneal nerve
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DOI：
10.1007/s00221-002-1094-9
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发表时间：
2002-08-01
影响因子：
2
通讯作者：
Sinkjaer, T
中科院分区：
文献类型：
--
作者：
Khaslavskaia, S;Ladouceur, M;Sinkjaer, T
本研究的目的是调查是否重复电刺激腓总神经（CPN）与运动皮层的局灶性磁刺激引起的胫骨前肌（TA）肌肉的运动反应的变化。运动诱发电位（MEP）的刺激强度的125%的阈值放松的右TA之前，期间和之后的CPN的重复电刺激（列车的5个脉冲的1毫秒，频率为200 Hz，重复每秒30分钟的持续时间）。重复电刺激后诱发的TA肌MEP增加了104%（范围：18-263%），并且在神经刺激结束后增加维持长达110 min（范围：15-110 min）。TA肌肉MEP的增加与刺激-反应曲线阈值的降低有关。此外，在此期间，TA牵张反射的早期成分以及MEP的潜伏期没有显着变化。为了进一步测试MEP增加的起源，补充实验表明，经颅电刺激（TES）引起的MEP也增加，但程度较低（约50%）比TMS引起的MEP。可以得出结论，短期神经重复电刺激健康人参与者的下肢可以导致对侧MEP的长期增加。由于TES被认为主要激活皮层细胞的轴突而不是索马，所以MEP的增加不能完全由运动皮层细胞兴奋性的变化来解释，还可以由参与脊髓运动神经元兴奋的皮层下神经结构的变化来解释。本研究的结果允许推测，这将是可能的，使用重复电刺激在下肢肌无力和痉挛患者的康复。
The purpose of this study was to investigate whether repetitive electrical stimulation of the common peroneal nerve (CPN) is associated with changes in the motor response of the tibialis anterior (TA) muscle elicited by focal magnetic stimulation of the motor cortex. Motor evoked potentials (MEP) with a stimulation intensity of 125% of the threshold of the relaxed right TA were obtained before, during, and after repetitive electrical stimulation of the CPN (trains of five pulses of 1 ms, at a frequency of 200 Hz, repeated every second with a 30-min duration). The MEP of the TA muscle elicited after repetitive electrical stimulation were increased by 104% (range: 18-263%), and the increase was maintained for up to 110 min (range: 15-110 min) after the end of nerve stimulation. This increase in the MEP of the TA muscle was associated with a decrease in the threshold from the stimulation-response curve. Furthermore, during that period the early component of the TA stretch reflex as well as the latency of the MEP did not significantly change. To further test the origin of the increased MEP, complementary experiments showed that MEP elicited by transcranial electrical stimulation (TES) were also increased, but to a lesser degree (approximately 50%) than MEP elicited by TMS. It can be concluded that short-term nerve repetitive electrical stimulation of the lower extremities in healthy human participants can lead to a long-term increase in the contralateral MEP. As TES is believed to mainly activate the axon and not the soma of the cortical cells, the increased MEP cannot be explained exclusively by changes in the motor cortex cell excitability, but also by changes in subcortical neural structures involved in the excitation of spinal motoneurons. The results of this study allow the speculation that it would be possible to use repetitive electrical stimulation in the rehabilitation of patients with lower limb muscle weakness and spasticity.