Aggressive and diffuse coronary calcification in South Asian angina patients compared to Caucasians with similar risk factors
Aggressive and diffuse coronary calcification in South Asian angina patients compared to Caucasians with similar risk factors
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DOI：
10.1016/j.ijcard.2012.05.102
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发表时间：
2013-09-10
影响因子：
3.5
通讯作者：
Henein, M. Y.
中科院分区：
文献类型：
--
作者：
Koulaouzidis, G.;Nicoll, R.;Henein, M. Y.
背景资料：冠状动脉疾病的患病率和严重程度的种族差异是公认的，通常归因于危险因素的变化。本研究调查了两个年龄和性别匹配的南亚和高加索有症状心绞痛患者队列之间冠状动脉狭窄和冠状动脉钙化的差异。方法：我们确定了101例接受CT血管造影和钙评分的南亚起源的有症状心绞痛患者，并将其与101例年龄和性别匹配的高加索患者进行比较。结果：与白人相比，南亚人具有阻塞性和非阻塞性斑块的动脉节段的平均数量更多（分别为p=0.006和p=0.0003），三支血管疾病的患病率更高（p=0.0004）。同样，南亚人的平均CAC评分更高（p <0），并且在所有类别的CAC评分中，100-1000也更高，钙化和非钙化斑块的动脉节段数量也更高。这些结果在年龄>50岁的患者中更为明显，但在
Background: Ethnic differences in prevalence and severity of coronary artery disease are well established and are usually attributed to risk factors variation. This study investigates the differences in coronary artery narrowing and coronary calcification between two age-and gender-matched cohorts of South Asian and Caucasian symptomatic angina patients.Methods: We identified 101 symptomatic angina patients of South Asian origin who had undergone CT angiography and calcium scoring, and compared them with 101 age and gender matched Caucasian patients.Results: South Asians had a greater mean number of arterial segments with both obstructive and non-obstructive plaque than Caucasians (p=0.006 and p=0.0003, respectively) and higher prevalence of triple-vessel disease (p=0.0004). Similarly, South Asians had a higher mean CAC score (p0 and in all categories of CAC score 100-1000 were also higher, as was the number of arterial segments with calcified and non-calcified plaque. These results were more marked in patients aged >50 but in those