Ferroptosis: Death by Lipid Peroxidation.
Ferroptosis: Death by Lipid Peroxidation.
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DOI：
10.1016/j.tcb.2015.10.014
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发表时间：
2016-03
影响因子：
19
通讯作者：
Stockwell BR
中科院分区：
文献类型：
--
作者：
Yang WS;Stockwell BR
铁亡是一种受调节的细胞死亡形式，由脂质修复酶谷胱甘肽过氧化物酶4（GPX 4）活性丧失以及随后基于脂质的活性氧物质（特别是脂质氢过氧化物）的积累驱动。这种形式的铁依赖性细胞死亡在遗传学、生物化学和形态学上不同于其他细胞死亡形式，包括细胞凋亡、不受调节的坏死和坏死性凋亡。亚铁凋亡受特定途径调节，并涉及不同的生物学背景。在这里，我们总结了铁凋亡的发现，铁凋亡的调节机制，以及其日益重视的正常和病理生理学的相关性。
Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species, particularly lipid hydroperoxides. This form of iron-dependent cell death is genetically, biochemically, and morphologically distinct from other cell death modalities, including apoptosis, unregulated necrosis, and necroptosis. Ferroptosis is regulated by specific pathways and is involved in diverse biological contexts. Here, we summarize the discovery of ferroptosis, the mechanism of ferroptosis regulation, and its increasingly appreciated relevance to both normal and pathological physiology.