[Cordyceps sinensis in protection of the kidney from cyclosporine A nephrotoxicity].
[Cordyceps sinensis in protection of the kidney from cyclosporine A nephrotoxicity].
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作者：
X. Zhao;L. Li
为探讨冬虫夏草(CS)对环孢素A(CsA)肾毒性(CsA-NX)的保护作用及其可能机制，采用光镜、电子显微镜和形态计量学方法研究了CsA对大鼠肾脏的影响。CsA注射后第15天，光镜下可见近端肾小管上皮细胞明显空泡化、坏死，光镜下可见线粒体肿胀。形态计量学研究显示，CS组近、远端小管上皮面积均大于对照组。慢性CsA-NX各期肾小管上皮细胞均有明显的空泡化(90%)和坏死。间质水肿伴轻度纤维化。电子显微镜下可见线粒体异常。形态计量学分析显示，CsA组肾小管、肾小球上皮细胞面积均小于CS组。急性实验和慢性实验均表明，CS对CsA-NX的肾脏有保护作用，并能改善肾小球和间质的损伤。
To explore the protective effect of cordyceps sinensis (CS) on cyclosporine A nephro-toxicity (CsA-Nx) and the possible mechanism, we studied the kidney changes induced by CsA in rats by light microscopy (LM), electronic microscopy (EM) and morphometrical analysis. At the 15th day after receiving CsA, prominent vacuolation and necrosis were noted microscopically in proximal tubular cells and mitochondria swelling electronmicroscopically. Morphometrical study showed that the epithelial areas of both proximal and distal tubules in the CS group were larger than those of the control group. There were obvious vacuolation (90%) and necrosis in proximal tubular cells at different stages of chronic CsA-Nx. Interstitial edema with mild fibrosis was observed. Mitochondria abnormality was seen electronmicroscopically. Morphometrical analysis showed that the epithelial cell areas of tubules and glomeruli were smaller in the CsA group than those in the CS group. Both acute and chronic experiments showed that CS could protect the kidney from CsA-Nx and ameliorate the glomerular and interstitial injuries.