Resting-state fMRI correlations: From link-wise unreliability to whole brain stability
Resting-state fMRI correlations: From link-wise unreliability to whole brain stability
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DOI：
10.1016/j.neuroimage.2017.06.006
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发表时间：
2017-08-15
期刊：
影响因子：
5.7
通讯作者：
Deco, Gustavo
中科院分区：
文献类型：
--
作者：
Pannunzi, Mario;Hindriks, Rikkert;Deco, Gustavo
许多研究已经详细描述了自发性剧烈波动的功能结构，证明了其作为生物标志物的潜在相关性。然而，对其一致性的系统研究还处于起步阶段。在这里，我们在一个独特的数据集中分析了静息状态功能连接性(FC)的受试者内和受试者之间的变异性和重测可靠性，该数据集包括来自5个受试者的多个fMRI扫描(42)和来自50个受试者的50个单次扫描。我们采用了一个统计框架，使我们能够确定FC中不同的变异性来源。我们表明，通过对每个受试者使用多个扫描，可以显著改善单一链接的低可靠性。此外，与前人的研究相比，我们发现FC可靠性的空间异质性并不显著。最后，我们证明，尽管单个链接的可靠性较低，但全脑FC矩阵所携带的信息是健壮的，可以作为功能指纹从群体中识别单个受试者。
The functional architecture of spontaneous BOLD fluctuations has been characterized in detail by numerous studies, demonstrating its potential relevance as a biomarker. However, the systematic investigation of its consistency is still in its infancy. Here, we analyze within-and between-subject variability and test-retest reliability of resting-state functional connectivity (FC) in a unique data set comprising multiple fMRI scans (42) from 5 subjects, and 50 single scans from 50 subjects. We adopt a statistical framework that enables us to identify different sources of variability in FC. We show that the low reliability of single links can be significantly improved by using multiple scans per subject. Moreover, in contrast to earlier studies, we show that spatial heterogeneity in FC reliability is not significant. Finally, we demonstrate that despite the low reliability of individual links, the information carried by the whole-brain FC matrix is robust and can be used as a functional fingerprint to identify individual subjects from the population.