Photolytic and photocatalytic degradation of doxazosin in aqueous solution
Photolytic and photocatalytic degradation of doxazosin in aqueous solution
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DOI：
10.1016/j.scitotenv.2020.140131
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发表时间：
2020-10-20
影响因子：
9.8
通讯作者：
Trebse, Polonca
中科院分区：
文献类型：
--
作者：
Bujak, Ivana Tartaro;Kralj, Mojca Bavcon;Trebse, Polonca
多沙唑嗪（DOX）是一种选择性α受体阻滞剂，作为一种有效的抗高血压药物广泛应用于临床.这是一种经常使用的处方药，因此，环境和生态毒理学研究在水生物种和人类的接触和风险方面非常重要。本研究重点研究了多沙唑嗪在不同模拟条件下的光解和TiO 2光催化降解过程，并重点对降解产物进行了鉴定。光解（无TiO 2）实验中进行的存在和不存在的氧气，而多沙唑嗪水溶液的光催化降解进行了恒定的氧气流量下。DOX降解在TiO 2/UVA光催化实验中比在光解过程（UVA和UVC，UVC-N-2）期间更有效。具有电喷雾电离的LC-HRMS分析允许观察取决于反应条件（存在或不存在氧气，CO2）的几种主要降解产物的形成。根据精确的质量测量、同位素分布和裂解模式鉴定转化产物。其中，占主导地位的C17 H21 N5 O3和C12 H23 N5 O 4（二氧六环的裂解），和C23 H25 N5 O 7（羟基化）。采用V. ftscheri发光细菌进行毒性测试，结果表明，样品在光解条件下的毒性高于光催化条件下的毒性，这可能与降解产物的形成有关。(C)2020爱思唯尔B. V.保留所有权利。
Doxazosin (DOX), a selective alpha blocker, is widely used in medical therapy as an effective antihypertensive agent. It is a frequently prescribed drug and for this reason, environmental and ecotoxicological research is of great importance in terms of exposure and risk for both aquatic species and humans. In this study we focused on photolytic and TiO2 photocatalytic degradation processes of doxazosin under different simulated conditions, with the emphasis on identification of degradation products. Photolytic (without TiO2) experiments were performed in the presence and absence of oxygen, while photocatalytic degradation of doxazosin aqueous solution has been carried out under constant oxygen flow. DOX degradation was more efficient in the TiO2/UVA photocatalytic experiment than during photolytic processes (UVA and UVC, UVC-N-2).LC-HRMS analyses with electrospray ionization allowed observing the formation of several major degradation products depending on the reaction conditions (presence or absence of oxygen, photocatalysis). The transformation products were identified based on exact mass measurements, isotopic distribution, and fragmentation pattern. Among them, dominated C17H21N5O3 and C12H23N5O4 (cleavage of the dioxane cycle), and C23H25N5O7 ( hydroxylation). The detailed degradation pathway has been proposed.Toxicity testing with V. ftscheri luminescent bacteria revealed higher toxicity of samples in photolytic rather than photocatalytic experiments which might be attributed to the formation of different products. (C) 2020 Elsevier B.V. All rights reserved.