Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge-Conversional Polyion Complex Micelles
Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge-Conversional Polyion Complex Micelles
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DOI：
10.1002/anie.200905264
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Kataoka, Kazunori
中科院分区：
文献类型：
--
作者：
Lee, Yan;Ishii, Takehiko;Kataoka, Kazunori
（图为）站起来，传递！免疫球蛋白G（IgG）可以通过电荷转换修饰，然后用阳离子嵌段共聚物处理，形成聚离子复合物（PIC）胶束（见图片），进入活细胞的细胞质。IgC的生物活性在细胞中以pH依赖性方式选择性恢复，从而通过IgC与细胞内靶分子的结合来控制人肝癌细胞的生长。
(Figure Presented) Stand and deliver! Immunoglobulin G (IgG) can be delivered into the cytoplasm of living cells by charge-conversional modification followed by treatment with a cationic block copolymer to form polyion complex (PIC) micelles (see picture). The bioactivity of the IgC selectively recovers in the cell in a pH-dependent manner, thereby controlling the growth of human hepatoma cells through IgC binding to intracellular target molecules.