Disuse exaggerates the detrimental effects of alcohol on cortical bone
Disuse exaggerates the detrimental effects of alcohol on cortical bone
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DOI：
10.1097/01.alc.0000047348.23797.6e
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发表时间：
2003-01-01
影响因子：
3.2
通讯作者：
Turner, RT
中科院分区：
文献类型：
--
作者：
Hefferan, TE;Kennedy, AM;Turner, RT
背景：酗酒会增加患骨质疏松症的风险。然而，共病因素可能在酒精相关性骨折的发病机制中发挥重要作用。骨骼的次优机械负荷是骨丢失的公认危险因素，一些酗酒者可能会由于体力活动减少、肌肉萎缩或两者兼而有之而发生。饮酒和减少体力活动对骨代谢的影响还没有得到很好的研究。本研究的目的是确定机械戒酒是否会改变慢性酒精滥用大鼠的骨代谢。方法：在6月龄雄性大鼠的饮食中(35%卡路里摄入量)给予酒精4周。在实验的最后2周，大鼠后肢卸载以防止动态负重。结果：在胫骨骨干骨膜表面，酒精和后肢单独卸载可降低骨矿周长、骨矿沉积率和骨形成率。此外，酒精，但不是后肢负荷，增加了皮质内的骨吸收。酒精和后肢负重分别抑制骨形成的有害作用是相加的；两个变量之间没有交互作用。结论：减重通过进一步抑制骨形成，加重了酒精对成年雄性大鼠皮质骨的不利影响。这一发现表明，体力活动减少可能是酗酒者骨质疏松的共病因素。
Background: Alcohol abuse is associated with an increased risk for osteoporosis. However, comorbidity factors may play an important role in the pathogenesis of alcohol-related bone fractures. Suboptimal mechanical loading of the skeleton, an established risk factor for bone loss, may occur in some alcohol abusers due to reduced physical activity, muscle atrophy, or both. The effect of alcohol consumption and reduced physical activity on bone metabolism has not been well studied. The purpose of this study was to determine whether mechanical disuse alters bone metabolism in a rat model for chronic alcohol abuse.Methods: Alcohol was administered in the diet (35% caloric intake) of 6-month-old male rats for 4 weeks. Rats were hindlimb-unloaded the final 2 weeks of the experiment to prevent dynamic weight bearing. Afterward, cortical bone histomorphometry was evaluated at the tibia-fibula synostosis.Results: At the periosteal surface of the tibial diaphysis, alcohol and hindlimb unloading independently decreased the mineralizing perimeter, mineral apposition rate, and bone formation rate. In addition, alcohol, but not hindlimb unloading, increased endocortical bone resorption. The respective detrimental effects of alcohol and hindlimb unloading to inhibit bone formation were additive; there was no interaction between the two variables.Conclusions: Reduced weight bearing accentuates the detrimental effects of alcohol on cortical bone in adult male rats by further inhibiting bone formation. This finding suggests that reduced physical activity may be a comorbidity factor for osteoporosis in alcohol abusers.