Wybutosine biosynthesis: Structural and mechanistic overview
Wybutosine biosynthesis: Structural and mechanistic overview
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DOI：
10.4161/15476286.2014.992271
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发表时间：
2014-12-01
期刊：
影响因子：
4.1
通讯作者：
Atta, Mohamed
中科院分区：
文献类型：
--
作者：
Perche-Letuvee, Phanelie;Molle, Thibaut;Atta, Mohamed
在过去的10年里，对怀布托辛（ybutosine，yW）生物合成途径的遗传学、酶学和结构组成的研究取得了重大进展。这些研究在扩大我们对yW生物合成的理解方面发挥了关键作用，并揭示了意想不到的进化联系，目前正在解开。催化这一途径的5个步骤的酶，从基因编码的鸟苷到wybutosine基地，提供了一个惊人的反应机制，将在这篇评论文章中讨论的合奏。
Over the last 10years, significant progress has been made in understanding the genetics, enzymology and structural components of the wybutosine (yW) biosynthetic pathway. These studies have played a key role in expanding our understanding of yW biosynthesis and have revealed unexpected evolutionary ties, which are presently being unraveled. The enzymes catalyzing the 5 steps of this pathway, from genetically encoded guanosine to wybutosine base, provide an ensemble of amazing reaction mechanisms that are to be discussed in this review article.