APOLIPOPROTEIN-E, SURVIVAL IN ALZHEIMERS-DISEASE PATIENTS, AND THE COMPETING RISKS OF DEATH AND ALZHEIMERS-DISEASE
APOLIPOPROTEIN-E, SURVIVAL IN ALZHEIMERS-DISEASE PATIENTS, AND THE COMPETING RISKS OF DEATH AND ALZHEIMERS-DISEASE
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DOI：
10.1212/wnl.45.7.1323
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发表时间：
1995-07-01
期刊：
影响因子：
9.9
通讯作者：
HAINES, JL
中科院分区：
文献类型：
--
作者：
CORDER, EH;SAUNDERS, AM;HAINES, JL
载脂蛋白E(APOE)epsilon 4等位基因会增加患者患阿尔茨海默病(AD)的风险，而epsilon 2等位基因会降低患者患阿尔茨海默病的风险。我们比较了具有不同数目的epsilon 4等位基因的受试者在AD发病后的存活率，并评估了基因频率随年龄的变化。研究对象包括两组：无亲缘关系的AD患者和对照组，以及74个多发AD家系的患病成员和未患病成员。在两组受试者中，发病生存期随着发病年龄的增加而减少，女性患者的生存期更长，与epsilon 4基因剂量无关。随着年龄的增长，epsilon 2/epsilon 3基因变得更加常见(p=0.004)。在所有患者组中，epsilon 4等位基因的频率随着年龄的增长而减少，但出人意料的是，在对照组中保持不变。我们的结论是，AD的进展与epsilon 4基因剂量没有很强的相关性，AD在女性中的较高患病率可能与受影响女性的更长生存时间有关，AD和死亡是涉及APOE的竞争风险，这种风险随着时间的推移而变化。
The apolipoprotein E (APOE) epsilon 4 allele carries an increased risk of a patient developing Alzheimer's disease (AD) while the epsilon 2 allele carries a decreased risk. We compared survival from the onset of AD in subjects with different numbers of epsilon 4 alleles and evaluated changes in genotypic frequencies with age. Two subject groups were investigated: unrelated AD case and control subjects, and affected and unaffected members from 74 multiplex AD families. In both subject groups, survival from onset decreased with increasing onset age, was longer in women and was unrelated to epsilon 4 gene dose. The epsilon 2/epsilon 3 genotype became more common with age (p = 0.004). The epsilon 4 allele decreased in frequency with age in all patient groups but, unexpectedly, remained unchanged in control subjects. We conclude that the progression of AD is not strongly related to epsilon 4 gene dose, that the higher prevalence of AD in women may involve the longer survival of affected women, and that AD and death are competing risks involving APOE that change over time.