New Material Design Strategy for Chromatographic Separation Steps in Bio‐Recovery and Downstream Processing
New Material Design Strategy for Chromatographic Separation Steps in Bio‐Recovery and Downstream Processing
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生物回收和下游加工中色谱分离步骤的新材料设计策略
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
J. Strube
中科院分区：
文献类型：
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作者：
Eugene Ndocko Ndocko;R. Ditz;Jan‐Pablo Josch;J. Strube
在生物过程设计中，对更高效率、更好经济性和更可持续性的日益增长的需求导致了以高通量筛选和平台技术的实施为特征的方法。所提出的方法结合了一个先验的材料设计策略，选择材料与工艺开发和设计，以解决所有涉及的元素的全部优化潜力。设计策略与经济过程评估直接相关，为实施提供定量数据。在所提出的理论研究中，不同的材料设计参数如孔结构是不同的。一个严格的材料设计模型，提出了所谓的不规则性内的多孔系统。
The increasing demand for higher efficiency, better economy, and more sustainability in bioprocess design has led to approaches characterized by high-throughput screening and the implementation of platform technologies. The presented approach incorporates an a priori material design strategy for selective materials in combination with process development and design to address the full optimization potential of all elements involved. The design strategies are directly linked with an economic process assessment to provide quantitative data for the implementation. Different material design parameters like pore structure were varied in the presented theoretical study. A rigorous material design model is proposed for so-called irregularities within the porous system.