Effects of Heat Stress on Postabsorptive Metabolism and Energetics
Effects of Heat Stress on Postabsorptive Metabolism and Energetics
复制标题
DOI：
10.1146/annurev-animal-031412-103644
复制
发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Rhoads, Robert P., Jr.
中科院分区：
文献类型：
--
作者：
Baumgard, Lance H.;Rhoads, Robert P., Jr.
环境诱导的体温过高会损害动物生产效率并危及动物福利。传统上认为，热应激期间产量下降是由于营养摄入量减少。我们的观察结果挑战了这一教条，并表明热应激动物采用新的顺势策略来指导代谢和燃料选择的优先顺序，而不依赖于营养摄入或能量平衡。全身生理学的改变支持碳水化合物代谢的转变，通过基础和刺激循环胰岛素水平等变化明显。肝细胞和肌细胞代谢也显示出在热应激期间葡萄糖产生和使用的明显差异。也许最有趣的是，考虑到热应激动物的能量不足，脂肪组织的脂肪动员明显缺乏，加上对脂解刺激的反应性降低。因此，热应激反应显着改变吸收后的碳水化合物，脂质和蛋白质代谢的独立减少饲料摄入量通过协调变化的燃料供应和利用的多个组织。
Environmental-induced hyperthermia compromises efficient animal production and jeopardizes animal welfare. Reduced productive output during heat stress was traditionally thought to result from decreased nutrient intake. Our observations challenge this dogma and indicate that heat-stressed animals employ novel homeorhetic strategies to direct metabolic and fuel selection priorities independent of nutrient intake or energy balance. Alterations in systemic physiology support a shift in carbohydrate metabolism, evident through changes such as basal and stimulated circulating insulin levels. Hepatocyte and myocyte metabolism also show clear differences in glucose production and use during heat stress. Perhaps most intriguing, given the energetic shortfall of the heat-stressed animal, is the apparent lack of fat mobilization from adipose tissue coupled with a reduced responsiveness to lipolytic stimuli. Thus, the heat stress response markedly alters postabsorptive carbohydrate, lipid, and protein metabolism independently of reduced feed intake through coordinated changes in fuel supply and utilization by multiple tissues.