Daughters of Mothers Who Smoke: A Population-based Cohort Study of Maternal Prenatal Tobacco use and Subsequent Prenatal Smoking in Offspring.
Daughters of Mothers Who Smoke: A Population-based Cohort Study of Maternal Prenatal Tobacco use and Subsequent Prenatal Smoking in Offspring.
复制标题
吸烟母亲的女儿：一项基于人群的关于母亲产前烟草使用和后代产前吸烟的队列研究。
DOI：
10.1111/ppe.12330
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发表时间：
2017
影响因子：
2.8
通讯作者：
Mueller,BethA
中科院分区：
文献类型：
--
作者：
Ncube,ColletteN;Mueller,BethA
背景：产前接触烟草与母亲和儿童的不良健康结果有关，并与后代吸烟和尼古丁依赖的风险增加有关。本研究的目的是检查女儿产前吸烟的风险与母亲产前吸烟的关系。方法：我们采用基于人群的队列研究设计，分别使用华盛顿州1984-96年和1996-2013年出生的母亲和女儿的相关生命记录数据。感兴趣的暴露是母亲产前吸烟（怀孕期间任何时候吸烟与不吸烟），而结果是女儿产前吸烟（评估类似）。我们使用多变量对数二项回归来获得相对风险（RR）和95%置信区间（CI）的估计值。结果与未暴露的女儿相比，暴露于母亲产前吸烟的女儿在怀孕期间吸烟的可能性更大（RR 1.78, 95% CI 1.72, 1.84，经女儿分娩年份、婚姻状况和教育程度以及母亲的种族/民族调整后）。结论在这个相对年轻的人群中，我们发现女儿在孕期暴露于母亲产前吸烟的情况下，在以后的怀孕期间吸烟的风险增加，强调了产前暴露的重要性。导致产前吸烟的机制是多因素的，可能包括行为、遗传、表观遗传和环境因素。了解产前吸烟的这一危险因素可以指导卫生保健提供者更好地针对高危人群进行戒烟干预。
BackgroundPrenatal exposure to tobacco is associated with adverse health outcomes for the mother and child, and has been associated with an increased risk of tobacco smoking and nicotine dependence in offspring. The objective of this study was to examine the risk of prenatal smoking, among daughters, associated with maternal prenatal smoking.MethodsWe used a population‐based cohort study design, with linked vital records data of mothers and daughters delivering 1984–96 and 1996–2013, respectively, in Washington State. The exposure of interest was mothers’ prenatal smoking (any vs. no smoking at any time during pregnancy), while the outcome was daughters’ prenatal smoking (similarly assessed). We used multivariable log‐binomial regression to obtain estimates of the relative risk (RR) and 95% confidence interval (CI).ResultsDaughters exposed to maternal prenatal smoking were more likely to smoke during their pregnancy, compared to unexposed daughters (RR 1.78, 95% CI 1.72, 1.84, adjusted for the year the daughter delivered, her marital status and educational attainment, and the mothers’ race/ethnicity).ConclusionsIn this relatively young population, we found that daughters exposed to maternal prenatal smoking have an increased risk of smoking later on during their own pregnancy, emphasizing the importance of exposures during the prenatal period. The mechanisms leading to prenatal smoking are multifactorial and likely include behavioural, genetic, epigenetic and environmental factors. An understanding of this risk factor for prenatal smoking may guide health care providers to better target smoking cessation interventions to at‐risk populations.