Inhibition of benz[a]pyrene-induced mammary carcinogenesis by retinyl acetate.
Inhibition of benz[a]pyrene-induced mammary carcinogenesis by retinyl acetate.
复制标题
乙酸视黄酯抑制苯并[a]芘诱导的乳腺癌发生。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
R. E. Albert
中科院分区：
文献类型：
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作者：
D. L. McCormick;F. J. Burns;R. E. Albert
相对于50 mg苯并[a]芘（BP）灌胃，在不同时期给予250 ppm的视黄酯膳食补充剂可显著抑制未交配雌性LEW/Mai大鼠乳腺癌的诱导。以给药第0天为时间，从第2周至第1周、第1周至第90周、第20周至第90周、第2周至第90周接受类维生素a治疗的组与对照组相比，肿瘤反应显著降低。+1至+20给药计划对癌变的抑制是暂时的；肿瘤产量最初受到抑制，但在第60周恢复到控制水平。50日龄大鼠乳腺的放射自显影分析表明，补充视黄醇醋酸酯2周可显著降低乳腺导管、肺泡和终末芽结构的实质细胞标记指数。在给药后1周开始补充视黄醇醋酸酯可显著减少终末导管增生的数量。在致癌物可用之前和期间短期服用视黄醇醋酸酯对癌变的抑制作用，以及致癌物后长期服用类视黄醇对癌变的抑制作用，可能涉及对大鼠乳腺的抗增殖作用。
The administration of a 250-ppm retinyl acetate dietary supplement for various periods relative to intragastric administration of 50 mg benzo[a]pyrene (BP) significantly inhibited the induction of mammary cancers in virgin female inbred LEW/Mai rats. with day of BP administration taken as time 0, groups receiving the retinoid from weeks -2 to +1, +1 to +90, +20 to +90, and -2 to +90 showed a significant reduction in tumor response as compared to controls. The inhibition of carcinogenesis achieved by a +1 to +20 administration schedule was temporary; the tumor yield was suppressed initially but returned to control levels by week 60. Autoradiographic analysis of mammary glands from 50-day-old rats indicated that a 2-week exposure to supplemental retinyl acetate significantly reduced the mammary gland parenchymal cell labeling index in ductal, alveolar, and terminal end bud structures. Beginning the retinyl acetate supplement 1 week after the administration of BP significantly reduced the number of terminal ductal hyperplasias. The inhibition of carcinogenesis achieved by a short period of retinyl acetate administration before and during the period of carcinogen availability as well as the inhibition achieved by long-term postcarcinogen retinoid exposure may involve an antiproliferative effect on the rat mammary gland.