Changes in Histological Features of Nasal Polyps in a Korean Population over a 17-year Period
Changes in Histological Features of Nasal Polyps in a Korean Population over a 17-year Period
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DOI：
10.1177/0194599813495363
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发表时间：
2013-09-01
影响因子：
3.4
通讯作者：
Shin, Seung Youp
中科院分区：
文献类型：
--
作者：
Kim, Su Jin;Lee, Kun Hee;Shin, Seung Youp
目的鼻息肉根据炎性细胞的浸润情况可分为嗜酸性和非嗜酸性。病理性息肉类型的患病率存在地域差异。本研究的目的是评估韩国人鼻息肉组织学亚型随时间的变化。研究设计采用组织学分析的回顾性横断面研究。设置一个单一的学术医学中心。研究对象和方法1993-1994年(A组)至2010-2011年(B组)共230例鼻息肉患者。标本固定在福尔马林中，包埋在石蜡块中。切片用苏木精-伊红(H&E)染色，随后由2名作者进行了审查。记录每高倍视野的嗜酸性粒细胞(HPF)数量，以及其他细胞、上皮和间质标志物。平均嗜酸性粒细胞计数/HPF由A组的6.8升至B组的19.3(P=0.006)。嗜酸性息肉的患病率也从A组的24.0%上升到B组的50.9%(P<；.001)。在其他组织学指标中，淋巴细胞、基底膜增厚和腺体增生在两组间有显著差异。结论通过对韩国1个学术医学中心1993年和2011年鼻息肉的组织病理学结果进行比较，发现嗜酸性鼻息肉的患病率显著增加，这种鼻息肉在亚洲人中是罕见的。
ObjectiveNasal polyps can be categorized as eosinophilic or non-eosinophilic, depending on inflammatory cell infiltration. There are geographical differences in the prevalence of types of pathologic polyps. The aim of this study was to evaluate the change in the prevalence of histological subtypes of polyps over time in a Korean population.Study DesignA retrospective cross-sectional study with histologic analysis.SettingA single academic medical center.Subjects and MethodsA total of 230 patients with nasal polyps were enrolled between 1993-1994 (group A) and 2010-2011 (group B). Specimens were fixed in formalin and embedded into paraffin blocks. Slides were stained with hematoxylin-eosin (H&E) and were subsequently reviewed by 2 of the authors. The numbers of eosinophils per high power field (HPF), as well as other cellular, epithelial, and stromal markers, were recorded.ResultsWe compared nasal polyp eosinophil counts according to time period. The average eosinophil count/HPF increased from 6.8 in group A to 19.3 in group B (P = .006). The prevalence of eosinophilic polyps also increased from 24.0% in group A to 50.9% in group B (P < .001). Among other histologic markers, lymphocytes, basement membrane thickening, and gland hyperplasia showed significant differences between groups.ConclusionAfter comparison of histopathologic findings of nasal polyps from 1993 and 2011 at 1 academic medical center in Korea, the prevalence of eosinophilic nasal polyps, which are known to be rare among Asians, has significantly increased.