Colloidal properties and in vitro evaluation of Hydroxy ethyl cellulose coated iron oxide particles for targeted drug delivery
Colloidal properties and in vitro evaluation of Hydroxy ethyl cellulose coated iron oxide particles for targeted drug delivery
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DOI：
10.1016/j.msec.2017.04.030
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发表时间：
2017-09-01
影响因子：
7.9
通讯作者：
Isci, Sevim
中科院分区：
文献类型：
--
作者：
Bekaroglu, Maide Gokce;Isci, Yavuz;Isci, Sevim
在这项研究中，超顺磁性氧化铁（Fe3O4）纳米粒子制备的靶向药物输送应用通过控制与纤维素聚合物，即羟乙基纤维素（HEC）的胶体性质。Fe_3O_4颗粒用HEC在不同的聚合物浓度范围内处理。研究了分散体的流变学、电动力学、磁流变学和形态学特性，通过HEC包覆Fe3O4颗粒，获得了无毒、生物相容的多功能磁性颗粒。完全包覆的HEC和氧化铁颗粒进行了热，磁和体外毒性测试。然后将广泛用于癌症治疗的抗癌药物盐酸阿霉素（DOX）负载到纳米颗粒上，并测定其载药效率。最后，研究了载DOX颗粒对癌细胞的影响，以报告纳米药物系统，该系统可能在治疗剂的设计中开辟新的可能性。结果表明，本研究合成的纳米粒子可用于磁操纵靶向给药系统、成像、磁热疗等。(C)2017爱思唯尔B.V.保留所有权利。
In this study, superparamagnetic iron oxide (Fe3O4) nanoparticles were prepared for the targeted drug delivery applications by controlling the colloidal properties with a cellulosic polymer that is Hydroxy ethyl cellulose (HEC). Fe3O4 particles were treated with HEC in a variable range of polymer concentration. Rheological, electrokinetic, magnetorheological and morphological properties of the dispersions were investigated to have stable and fully covered surfaces of Fe3O4 particles by coating with HEC and obtaining non-toxic biocompatible multifunctional magnetic particles. Fully coated HEC and iron-oxide particles were characterized thermally, magnetically and tested for toxicity in vitro. Then Doxorubicin hydrochloride (DOX), which is an anticancer drug widely used for cancer therapies, was loaded onto nanoparticles and their drug loading efficiency was determined. Finally, effects of DOX-loaded particles on the cancer cells were examined to report a nano drug system which can potentially open up new possibilities in the design of therapeutic agents. Results indicated that the synthesized nanoparticles in this study could be suitable to magnetically manipulated targeted delivery systems, imaging, magnetic hyperthermia treatments. (C) 2017 Elsevier B.V. All rights reserved.