Rapid Changes in Serum Lipid Profiles during Combination Therapy with Daclatasvir and Asunaprevir in Patients Infected with Hepatitis C Virus Genotype 1b.
Rapid Changes in Serum Lipid Profiles during Combination Therapy with Daclatasvir and Asunaprevir in Patients Infected with Hepatitis C Virus Genotype 1b.
复制标题
DOI：
10.5009/gnl17179
复制
发表时间：
2018-03-15
期刊：
影响因子：
3.4
通讯作者：
Kobayashi Y
中科院分区：
文献类型：
--
作者：
Chida T;Kawata K;Ohta K;Matsunaga E;Ito J;Shimoyama S;Yamazaki S;Noritake H;Suzuki T;Suda T;Kobayashi Y
近年来有报道称，丙型肝炎病毒（HCV）感染患者在直接抗病毒治疗期间血脂谱发生变化。然而，慢性 HCV 感染中脂质代谢紊乱的临床表现尚未完全阐明。在达卡他韦 (DCV) 和阿舒瑞韦 (ASV) 联合治疗期间，检测了基因 1b 型 HCV 感染患者的血清总胆固醇、低密度脂蛋白 (LDL) 和高密度脂蛋白 (HDL) 胆固醇和载脂蛋白水平的动态变化。第 4 周后，总胆固醇、LDL− 和 HDL 胆固醇水平迅速持续上升。载脂蛋白 (apo) A-I、apo B、apo C-II 和 apo C-III 水平在第 4 周显着高于第 0 周。相反，apo A-II 和 apo E 水平显着降低。 LDL-和HDL-胆固醇水平的差异分别与apo B和apo A-I呈正相关。有趣的是，在病毒学反应不持续的患者中，这些胆固醇水平在病毒突破或病毒复发后迅速下降。此外，apo A-I、apo B 和 apo C-III 水平也观察到类似的变化。使用 DCV 和 ASV 联合治疗清除 HCV 会导致血清脂质谱快速变化，表明 HCV 感染对脂质代谢紊乱有影响。
Changes in lipid profiles in patients infected with hepatitis C virus (HCV) during direct-acting antiviral therapy have been reported in recent years. However, the clinical aspects of disturbed lipid metabolism in chronic HCV infection have not been fully elucidated. Dynamic changes in serum total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol and apolipoprotein levels in patients infected with HCV genotype 1b were examined during combination therapy with daclatasvir (DCV) and asunaprevir (ASV). Total, LDL−, and HDL-cholesterol levels increased rapidly and persistently after week 4. Apolipoprotein (apo) A-I, apo B, apo C-II, and apo C-III levels were significantly higher at week 4 than at week 0. In contrast, apo A-II and apo E levels were significantly lower. The differences in LDL− and HDL-cholesterol levels were positively correlated with those of apo B and apo A-I, respectively. Interestingly, in patients with non-sustained virological response, these cholesterol levels decreased rapidly after viral breakthrough or viral relapse. Furthermore, similar changes were observed for apo A-I, apo B and apo C-III levels. Clearance of HCV using combination therapy with DCV and ASV results in rapid changes in serum lipid profiles, suggesting an influence of HCV infection on disturbed lipid metabolism.
登录
查看更多内容
影响因子：
13.5
作者：
Corey, Kathleen E.;Kane, Erin;Munroe, Craig;Barlow, Lydia L.;Zheng, Hui;Chung, Raymond T.
通讯作者：
Chung, Raymond T.
影响因子：
13.5
作者：
Backus, Lisa I.;Boothroyd, Derek B.;Mole, Larry A.
通讯作者：
Mole, Larry A.
影响因子：
13.5
作者：
Gopal, Kavitha;Johnson, Timothy C.;Min, Albert D.
通讯作者：
Min, Albert D.
影响因子：
3.7
作者：
Hashimoto, Satoru;Yatsuhashi, Hiroshi;Nakao, Kazuhiko
通讯作者：
Nakao, Kazuhiko
影响因子：
3.8
作者：
Diaz, Olivier;Delers, Francois;Andre, Patrice
通讯作者：
Andre, Patrice