Mapping the Orientation of White Matter Fiber Bundles: A Comparative Study of Diffusion Tensor Imaging, Diffusional Kurtosis Imaging, and Diffusion Spectrum Imaging
Mapping the Orientation of White Matter Fiber Bundles: A Comparative Study of Diffusion Tensor Imaging, Diffusional Kurtosis Imaging, and Diffusion Spectrum Imaging
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DOI：
10.3174/ajnr.a4714
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发表时间：
2016-07-01
影响因子：
3.5
通讯作者：
Jensen, J. H.
中科院分区：
文献类型：
--
作者：
Glenn, G. R.;Kuo, L. -W.;Jensen, J. H.
作者评价了DTI的纤维束方向和弥散峰度，并与弥散谱成像进行了比较，作为评估每种技术性能的标准。在3名志愿者的2次独立会议期间采集DTI、弥散峰度成像和弥散频谱成像数据集。虽然所有3种技术的方向估计具有可比的角度再现性，但与DTI相比，弥散峰度成像降低了整个白色物质的角度误差。扩散光谱成像和扩散峰度成像能够检测交叉纤维束。他们的结论是，从扩散峰度成像的纤维束方向估计有更少的系统误差比那些从DTI.背景和目的：白色物质纤维束追踪依赖于纤维束方向估计从扩散MR成像。然而，临床上可行的技术，如DTI和弥散峰度成像使用的假设，这可能会引入误差到体内方向估计。在这项研究中，纤维束方向从DTI和扩散峰度成像进行了比较，扩散光谱成像作为一个标准，以评估每种技术的性能。材料和方法：对于每个受试者，在2个独立的会话期间采集完整的DTI、弥散峰度成像和弥散频谱成像数据集，和纤维束取向估计通过使用每种技术的特定的理论假设。通过比较方向估计值来评估角度变异性和角度误差测量值。纤维束成像产生的3个重建也进行了检查和contrading.Results：方向估计从所有3种技术具有可比的角度再现性，但扩散峰度成像降低了角度误差在整个白色问题相比，DTI。弥散谱成像和弥散峰度成像能够检测交叉纤维束，相对于DTI，交叉纤维束对纤维束成像有显著影响。扩散光谱成像检测交叉纤维的灵敏度最高，但是，扩散光谱成像和扩散峰度成像tracts定性similar.CONCLUSIONS：纤维束方向估计从扩散峰度成像的系统误差小于DTI，这可以显着影响纤维束成像。此外，弥散峰度成像获得的纤维束成像与弥散频谱成像定性相当。由于扩散峰度成像具有比扩散光谱成像更短的典型扫描时间，因此扩散峰度成像可能更适合于各种临床和研究应用。
The authors evaluated fiber bundle orientations from DTI and diffusional kurtosis compared with diffusion spectrum imaging as a criterion standard to assess the performance of each technique. DTI, diffusional kurtosis imaging, and diffusion spectrum imaging datasets were acquired during 2 independent sessions in 3 volunteers. While orientation estimates from all 3 techniques had comparable angular reproducibility, diffusional kurtosis imaging decreased angular error throughout the white matter compared with DTI. Diffusion spectrum imaging and diffusional kurtosis imaging enabled the detection of crossing-fiber bundles. They conclude that fiber bundle orientation estimates from diffusional kurtosis imaging have less systematic error than those from DTI.BACKGROUND AND PURPOSE: White matter fiber tractography relies on fiber bundle orientation estimates from diffusion MR imaging. However, clinically feasible techniques such as DTI and diffusional kurtosis imaging use assumptions, which may introduce error into in vivo orientation estimates. In this study, fiber bundle orientations from DTI and diffusional kurtosis imaging are compared with diffusion spectrum imaging as a criterion standard to assess the performance of each technique.MATERIALS AND METHODS: For each subject, full DTI, diffusional kurtosis imaging, and diffusion spectrum imaging datasets were acquired during 2 independent sessions, and fiber bundle orientations were estimated by using the specific theoretic assumptions of each technique. Angular variability and angular error measures were assessed by comparing the orientation estimates. Tractography generated with each of the 3 reconstructions was also examined and contrasted.RESULTS: Orientation estimates from all 3 techniques had comparable angular reproducibility, but diffusional kurtosis imaging decreased angular error throughout the white matter compared with DTI. Diffusion spectrum imaging and diffusional kurtosis imaging enabled the detection of crossing-fiber bundles, which had pronounced effects on tractography relative to DTI. Diffusion spectrum imaging had the highest sensitivity for detecting crossing fibers; however, the diffusion spectrum imaging and diffusional kurtosis imaging tracts were qualitatively similar.CONCLUSIONS: Fiber bundle orientation estimates from diffusional kurtosis imaging have less systematic error than those from DTI, which can noticeably affect tractography. Moreover, tractography obtained with diffusional kurtosis imaging is qualitatively comparable with that of diffusion spectrum imaging. Because diffusional kurtosis imaging has a shorter typical scan time than diffusion spectrum imaging, diffusional kurtosis imaging is potentially more suitable for a variety of clinical and research applications.