Child abuse interacts with hippocampal and corpus callosum volume on psychophysiological response to startling auditory stimuli in a sample of veterans.
Child abuse interacts with hippocampal and corpus callosum volume on psychophysiological response to startling auditory stimuli in a sample of veterans.
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DOI：
10.1016/j.jpsychires.2019.01.011
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发表时间：
2019-04
影响因子：
4.8
通讯作者：
Dmitri A. Young;T. Neylan;L. Chao;A. O'Donovan;T. Metzler;S. Inslicht
中科院分区：
文献类型：
--
作者：
Dmitri A. Young;T. Neylan;L. Chao;A. O'Donovan;T. Metzler;S. Inslicht
与创伤后应激障碍（PTSD）有关的儿童虐待（CA）与海马和胼胝体（CC）体积的减少有关。然而，很少有研究探讨这些关系的心理生理变量与创伤暴露。因此，我们评估了CA和海马和CC体积之间的相互作用是否与退伍军人样本中增强恐惧增强的心理生理反应模式相关。参与海湾战争疾病更大规模研究的147名退伍军人参与者在无、模糊和高威胁条件下暴露于令人震惊的声音，并提供了MRI数据。采用临床医师创伤后应激障碍量表和创伤史问卷分别测量创伤后应激障碍和CA。通过肌电图、SCR和心率测量心理生理反应。重复测量混合线性模型被用来评估CA的显着性神经结构的相互作用。CA与海马和CC体积在心理生理反应幅度上相互作用，其中CA和海马体积较小的参与者在试验和威胁条件下具有更大的EMG（p< 0.01）和SCR（p< 0.05）幅度。具有CA和较小CC体积的参与者在试验和威胁条件下具有更大的SCR幅度（p< 0.01）。海马和海马体积介导的CA和心理生理反应幅度。CA可能通过海马和CC体积的减少影响心理生理反应。这些结构的体积减少可能表明神经功能性的、CA相关的威胁敏感性增加，这可能预示着PTSD易感性增加，以及在整个生命周期中对人际和社会产生不利影响。
Child abuse (CA), which is linked to posttraumatic stress disorder (PTSD), has been associated with a reduction in both hippocampal and corpus callosum (CC) volume. However, few studies have explored these relationships on psychophysiological variables related to trauma exposure. Therefore, we assessed whether the interaction between CA and hippocampal and CC volume were associated with enhanced fear potentiated psychophysiological response patterns in a sample of Veterans. 147 Veteran participants who were part of a larger study of Gulf War Illness were exposed to startling sounds in no, ambiguous, and high threat conditions and also provided MRI data. The Clinician Administered PTSD Scale and Trauma History Questionnaire were used to measure PTSD and CA respectively. Psychophysiological response was measured by EMG, SCR, and heart rate. Repeated-measures mixed linear models were used to assess the significance of CA by neural structure interactions. CA interacted with both hippocampal and CC volume on psychophysiological response magnitudes, where participants with CA and smaller hippocampal volume had greater EMG (p< 0.01) and SCR (p< 0.05) magnitudes across trials and over threat conditions. Participants with CA and smaller CC volume had greater SCR magnitudes across trials and over threat conditions (p< 0.01). Hippocampal and genu volume mediated CA and psychophysiological response magnitude. CA may impact psychophysiological response via a reduction in hippocampal and CC volume. Volumetric reduction in these structures may indicate a neurofunctional, CA-related increase in threat sensitivity, which could portend increased PTSD susceptibility and adverse interpersonal and social consequences across the lifespan.