VITAMIN-E IN KITTEN OXYGEN-INDUCED RETINOPATHY .2. BLOCKAGE OF VITREAL NEOVASCULARIZATION
VITAMIN-E IN KITTEN OXYGEN-INDUCED RETINOPATHY .2. BLOCKAGE OF VITREAL NEOVASCULARIZATION
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DOI：
10.1001/archopht.1979.01020020184021
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发表时间：
1979-01-01
影响因子：
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通讯作者：
ROSENBAUM, AL
中科院分区：
文献类型：
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作者：
PHELPS, DL;ROSENBAUM, AL
在为小猫的印度墨水注射视网膜平面制剂开发定量评分系统后，研究了维生素E（生育酚）对氧诱导视网膜病变的影响。在75只从第3天开始暴露于2或3天氧气的小猫中，从第1天开始用维生素E或安慰剂治疗显示，用维生素E治疗的小猫视网膜病变较少。维生素E作用机制的理论预测，如果仅在氧气暴露后给予维生素E，维生素E应该无效。这是在37只小猫与安慰剂或药物开始后，撤出氧气。出乎意料的是，在氧气暴露后用维生素E治疗的小猫中发现玻璃体内新生血管明显减少。
The effect of vitamin E (tocopherol) on oxygen-induced retinopathy was studied in the kitten after a quantitative scoring system was developed for their India ink injected retinal flat preparations. In 75 kittens exposed to 2 or 3 days of oxygen from day 3, treatment from day 1 with vitamin E or placebo disclosed that kittens treated with vitamin E had less retinopathy. Theories of the mechanism of action of vitamin E would predict that, if given only after the oxygen exposure, vitamin E should be ineffective. This was tested in 37 kittens with placebo or drug begun only after withdrawal from oxygen. Unexpectedly, significantly less intravitreal neovascularization was found in kittens treated with vitamin E after oxygen exposure.