Biosynthesis of cyclonerodiol
Biosynthesis of cyclonerodiol
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DOI：
10.1021/ja00478a041
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发表时间：
1978-05
影响因子：
15
通讯作者：
D. Cane;M. Shiao
中科院分区：
文献类型：
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作者：
D. Cane;M. Shiao
通过培养藤黑赤霉素，将甲羟戊酸钠[2-14C]掺入环戊类倍半萜环二醇中。化学降解同样位于C-4， C-8和C-l2。与观察到的标记模式一致的非生物合成途径涉及通过在乙烯基和中心双键上加水来使神经酰基焦磷酸环化。
Sodium [2-14C] mevalonate was incorporated into the cyclopentanoid sesquiterpene cyclonerodiol by cultures of Gibberella fujikuroi. Chemical degradation located the label equally at C-4, C-8, and C-l2. Abiosynthetic pathway consistent with the observed labeling pattern involves cyclizationof nerolidyl pyrophosphate by additionof water across the vinyl and cen-tral double bonds.