Alterations in Frontal Lobe Tracts and Corpus Callosum in Young Children with Autism Spectrum Disorder
Alterations in Frontal Lobe Tracts and Corpus Callosum in Young Children with Autism Spectrum Disorder
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DOI：
10.1093/cercor/bhp278
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发表时间：
2010-09-01
期刊：
影响因子：
3.7
通讯作者：
Chugani, Diane C.
中科院分区：
文献类型：
--
作者：
Kumar, Ajay;Sundaram, Senthil K.;Chugani, Diane C.
采用扩散张量成像纤维束成像和基于纤维束的空间统计方法，对32名自闭症谱系障碍（ASD，平均年龄：5岁）、12名非自闭症发育障碍儿童（DI，平均年龄：4.6岁）和16名典型发育儿童（TD，平均年龄：5.5岁）的额叶主要纤维束和胼胝体（CC）进行了研究。计算钩束（UF）、额枕下束（WO）、弓状束（AF）、扣带（Cg）、CC和皮质脊髓束的各种扩散和几何特性。与TO儿童相比，ASD和DI儿童的右侧UF、右侧Cg和CC、ASD儿童的右侧AF和DI儿童的双侧IFO的各向异性分数较低。ASD和DI儿童右侧AF的表观弥散系数均增加。与TD组相比，ASD组显示左侧UF长度较短，右侧UF长度、体积和密度增加; CC长度和密度增加;左侧Cg密度较高。与DI组相比，ASD组右侧UF的长度、体积和密度增加;左侧UF的体积增加;右侧AF和CC的长度增加。双侧UF和右侧AF的体积以及左侧UF的纤维密度与自闭症特征呈正相关。
Major frontal lobe tracts and corpus callosum (CC) were investigated in 32 children with autism spectrum disorder (ASD, mean age: 5 years), 12 nonautistic developmentally impaired children (DI, mean age: 4.6 years), and 16 typically developing children (TD, mean age: 5.5 years) using diffusion tensor imaging tractography and tract-based spatial statistics. Various diffusion and geometric properties were calculated for uncinate fasciculus (UF), inferior fronto-occipital fasciculus (WO), arcuate fasciculus (AF), cingulum (Cg), CC, and corticospinal tract. Fractional anisotropy was lower in the right UF, right Cg and CC in ASD and DI children; in right AF in ASD children; and in bilateral IFO in DI children, compared with TO children. Apparent diffusion coefficient was increased in right AF in both ASD and DI children. The ASD group showed shorter length of left UF and increased length, volume, and density of right UF; increased length and density of CC; and higher density of left Cg, compared with the TD group. Compared with DI group, ASD group had increased length, volume, and density of right UF; higher volume of left UF; and increased length of right AF and CC. Volume of bilateral UF and right AF and fiber density of left UF were positively associated with autistic features.