Human Cytomegalovirus Linked to Stroke in a Chinese Population
Human Cytomegalovirus Linked to Stroke in a Chinese Population
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人类巨细胞病毒与中国人群中风有关
DOI：
10.1111/j.1755-5949.2012.00326.x
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发表时间：
2012-01-01
影响因子：
5.5
通讯作者：
Cai, Jun
中科院分区：
文献类型：
--
作者：
Huang, Zheng-Rong;Yu, Li-Ping;Cai, Jun
目的：人巨细胞病毒（HCMV）与几种心血管疾病有关，包括动脉粥样硬化、冠心病和心脏移植动脉病。我们的目的是评估HCMV与脑卒中的关系。研究方法：实时聚合酶链反应（PCR）和酶联免疫吸附试验（ELISA）从200例诊断为中风和200名对照组的血浆样本进行分离。所有参与者都属于中风高血压遗传学调查（SHINING）研究。结果：脑卒中组HCMV血清阳性率为55.0%，明显高于对照组的23.5%（P <0.0001）; HCMV DNA的存在增加了中风的风险（未调整的比值比[OR]，3.98; 95%置信区间[CI]，2.59至6.11; P <0.0001）。缺血性卒中（未校正OR，4.01; 95%CI，2.57 - 6.24; P <0.0001）和出血性卒中（未校正OR，3.80; 95%CI，1.64 - 8.78; P = 0.0018）亚型的风险也增加。在校正年龄、性别、体重指数、高血压和吸烟后，HCMV的风险增加仍然显著（缺血性卒中：校正OR，4.07; 95% CI，2.52 - 6.32; P <0.0001;出血性卒中：校正OR，3.88; 95% CI，1.61 - 9.36; P = 0.0026）。结论：我们证明了HCMV感染和中风之间的新联系。这些发现可能为卒中的发病机制提供重要的见解。
Aim: Human cytomegalovirus (HCMV) is implicated in several cardiovascular disorders, including atherosclerosis, coronary heart disease, and cardiac transplant arteriopathy. We aimed to evaluate the relationship between HCMV and stroke. Methods: Real-time polymerase chain reaction (PCR) and ELISA were performed on plasma samples isolated from 200 patients diagnosed with stroke and 200 controls. All participants belonged to the Stroke Hypertension Investigation in Genetics (SHINING) study. Results: HCMV seropositivity was higher in the stroke group than in controls (55.0% vs. 23.5%; P < 0.0001). The presence of HCMV DNA increased the risk of stroke (unadjusted odds ratio [OR], 3.98; 95% confidence interval [CI], 2.59 to 6.11; P < 0.0001). Risks were also increased for the subtypes ischemic stroke (unadjusted OR, 4.01; 95% CI, 2.576.24; P < 0.0001) and hemorrhagic stroke (unadjusted OR, 3.80; 95% CI, 1.648.78; P= 0.0018). Increased risk with HCMV remained significant after adjustment for age, sex, body mass index, hypertension, and smoking (ischemic stroke: adjusted OR, 4.07; 95% CI, 2.526.32; P < 0.0001; hemorrhagic stroke: adjusted OR, 3.88; 95% CI, 1.619.36; P= 0.0026). Conclusions: We demonstrate a novel link between HCMV infection and stroke. These findings may provide important insights into the pathogenesis of stroke.