Interferon-γ Induces Class II MHC Antigens on RINm5F Cells
Interferon-γ Induces Class II MHC Antigens on RINm5F Cells
复制标题
干扰素-γ 在 RINm5F 细胞上诱导 II 类 MHC 抗原
作者：
A. Varey;P. Lydyard;B. Dean;P. H. van der Meide;J. Baird;A. Cooke
研究了重组γ-干扰素（rIFN-γ）诱导大鼠胰岛素瘤细胞系RINm 5 F表达主要组织相容性复合物（MHC）抗原的能力。细胞用对大鼠I类和II类MHC抗原特异性的单克隆抗体染色。RINm 5 F细胞内源性表达I类抗原;这被rIFN-γ增强。在RINm 5 F细胞上不能检测到II类抗原，但I-A和I-E都被rIFN-γ诱导。
The ability of recombinant interferon-γ (rIFN-γ) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-γ. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-γ.