Association between the metabolic syndrome and chronic kidney disease in Chinese adults
Association between the metabolic syndrome and chronic kidney disease in Chinese adults
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DOI：
10.1093/ndt/gfl759
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发表时间：
2007-04-01
影响因子：
6.1
通讯作者：
He, Jiang
中科院分区：
文献类型：
--
作者：
Chen, Jing;Gu, Dongfeng;He, Jiang
背景代谢综合征是西方人群中心血管和慢性肾脏疾病（CKD）的常见危险因素。我们研究了中国成年人代谢综合征与CKD风险之间的关系。在全国范围内对15160名35-74岁的中国成年人进行了横断面调查。代谢综合征定义为存在以下三种或三种以上危险因素：血压升高、低高密度脂蛋白（HDL）-胆固醇、高甘油三酯、血糖升高和腹部肥胖。CKD定义为肾小球滤过率估计值< 60 ml/min/1.73 m2，血清肌酐升高定义为男性>= 1.14 mg/dl，女性>= 0.97 mg/dl（中国35-44岁男性和女性的血清肌酐分别>= 95百分位数，无高血压或糖尿病）。与无代谢综合征的受试者相比，CKD和血清肌酐升高的多变量校正比值比[95%置信区间（CI）]分别为1.64（1.16，2.32）和1.36（1.07，1.73）。与无任何代谢综合征组分的参与者相比，CKD的多变量校正优势比（95%CI）为1.51（1.02，2.23）、1.50（0.97，2.32）、2.13（1.30，3.50）和2.72（1.50，4.93）。血清肌酐升高的多变量校正比值比（95%CI）分别为1.11（0.88，1.40）、1.39（1.07，2.04）、1.47（1.06，2.04）和2.00（1.32，3.03）。这些结果表明，代谢综合征可能是中国成人CKD的一个重要危险因素。
Background. The metabolic syndrome is a common risk factor for cardiovascular and chronic kidney disease (CKD) in Western populations. We examined the relationship between the metabolic syndrome and risk of CKD in Chinese adults.Methods. A cross-sectional survey was conducted in a nationally representative sample of 15 160 Chinese adults aged 35-74 years. The metabolic syndrome was defined as the presence of three or more of the following risk factors: elevated blood pressure, low high density lipoprotein (HDL)-cholesterol, high triglycerides, elevated plasma glucose and abdominal obesity. CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m(2) and elevated serum creatinine was defined as >= 1.14 mg/dl in men and >= 0.97 mg/dl in women (>= 95th percentile of serum creatinine in Chinese men and women aged 35-44 years without hypertension or diabetes, respectively).Results. The multivariate-adjusted odds ratios [95% confidence interval (CI)] of CKD and elevated serum creatinine in participants with compared to those without the metabolic syndrome were 1.64 (1.16, 2.32) and 1.36 (1.07, 1.73), respectively. Compared to participants without any components of the metabolic syndrome, the multivariate-adjusted odds ratios (95% CI) of CKD were 1.51 (1.02, 2.23), 1.50 (0.97, 2.32), 2.13 (1.30, 3.50) and 2.72 (1.50, 4.93) for those with 1, 2, 3, and 4 or 5 components, respectively. The corresponding multivariate-adjusted odds ratios (95% CI) of elevated serum creatinine were 1.11 (0.88, 1.40), 1.39 (1.07, 2.04), 1.47 (1.06, 2.04) and 2.00 (1.32, 3.03), respectively.Conclusions. These findings suggest that the metabolic syndrome might be an important risk factor for CKD in Chinese adults.