BIOLOGICAL DIFFERENCES BETWEEN ISCHEMIA, HYPOGLYCEMIA, AND EPILEPSY
BIOLOGICAL DIFFERENCES BETWEEN ISCHEMIA, HYPOGLYCEMIA, AND EPILEPSY
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DOI：
10.1002/ana.410240602
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发表时间：
1988-12-01
影响因子：
11.2
通讯作者：
SIESJO, BK
中科院分区：
文献类型：
--
作者：
AUER, RN;SIESJO, BK
缺血、低血糖和癫痫长期以来被认为会产生相似或相同的脑损伤。此外，这些侮辱已被假定为在其破坏作用的添加剂。这些概念是基于海马体和大脑皮层的神经病理学观察，以及能量衰竭（缺血。低血糖）和增加的能量需求（癫痫）类似地引起选择性神经元神经元坏死。最近，认为这三种损伤相同的其他基础已经从以下观察中发展出来：钙稳态的丧失是所有损伤共同的，并且选择性神经元坏死的兴奋性毒性机制存在于所有三种情况中。缺血、低血糖和癫痫之间的根本差异包括诱导的潜在神经化学变化、神经元复苏时间、神经元死亡的时间过程、选择性神经元坏死的分布以及可能释放的兴奋性毒素。乳酸的积累，涉及损害神经元以及神经元细胞体，也发生在不同的程度和不同的分布在三个条件。因此，全坏死的程度和分布在缺血、低血糖和癫痫中也是不同的。
Ischemia, hypoglycemia, and epilepsy have long been thought to produce similar or identical brain damage. Further more, these insults have been assumed to be additive in their damaging effects. These notions have been based on neuropathological observations in the hippocampus and cerebral cortex, and on the tenet that energy failure (ischemia. hypoglycemia) and increased demand for energy (epilepsy) similarly give rise to selective neuronal neuronal mecrosis Recently, other bases for considering these three insults identical have grown out of observations that loss of calcium homeostasis is common to all and that an excitotoxic mechanism of selective neuronal necrosis exists in all three conditions. Fundamental differences between ischemia, hypoglycemia, and epilepsy include the underlying neurochemical changes induced, the neuronal revival times, the time course of neuronal death, the distribution of selective neuronal necrosis, and the likely excitotoxins released. Lactic acid accumulation, implicated in damage to the neuropil as well as to neuronal cell bodies, also occurs to different degrees and in different distributions in the three conditions. The degree and distribution of pannecrosis is thus also different in ischemia, hypoglycemia, and epilepsy.