Local functional connectivity density is closely associated with the response of electroconvulsive therapy in major depressive disorder
Local functional connectivity density is closely associated with the response of electroconvulsive therapy in major depressive disorder
复制标题
局部功能连接密度与重度抑郁症电惊厥治疗的反应密切相关。
DOI：
10.1016/j.jad.2017.09.001
复制
发表时间：
2018-01-01
影响因子：
6.6
通讯作者：
Wang, Kai
中科院分区：
文献类型：
--
作者：
Wang, Jiaojian;Wei, Qiang;Wang, Kai
背景：电休克疗法（ECT）已被证明是治疗抑郁症（MDD）的有效方法。然而，ECT反应的神经解剖学基础在很大程度上仍然未知。方法：在本研究中，我们使用功能连接密度（FCD）和静息状态功能连接（RSFC）来确定23例MDD患者ECT前后静息状态活动变化与ECT反应之间的关系。并将识别出的神经指标作为分类特征，采用线性支持向量机（linear support vector machine，SVM）进行多变量模式分析，对23例ECT前MDD患者和25例性别、年龄、受教育年限匹配的健康对照者进行分类。结果发现，左侧中央前回和中央后回的局部FCD（lFCD）的变化，抑郁症患者ECT治疗前后汉密尔顿抑郁量表（HRSD）评分变化与CG治疗前、后左上级颞回（STG）、右颞上回（STG）评分变化显著相关。随后的功能连接分析显示，尽管与HRSD评分无相关性，但ECT后MDD患者右侧STG和右侧顶内沟（IPS）之间的功能连接显著降低。最后，基于SVM的分类达到了72.92%的准确性，敏感性为73.91%，特异性为72%by leave-one-out cross-validation.Conclusions：我们的研究结果表明，前/postCG和双边STG发挥重要作用，在MDD患者的ECT反应，和lFCD在这些领域可以作为一个生物标志物预测ECT反应。
Background: Electroconvulsive therapy (ECT) has been demonstrated to be an effective treatment of major depressive disorder (MDD). However, the neuroanatomical basis of response to ECT is still largely unknown.Methods: In present study, we used functional connectivity density (FCD) and resting-state functional connectivity (RSFC) to identify the relationship between the changes of resting-state activities and ECT responses in 23 MDD patients before and after ECT. In addition, the identified neural indices as classification characteristics were entered into multivariate pattern analysis using linear support vector machine (SVM) to classify 23 MDD patients before ECT from 25 gender, age and years of education matched healthy controls.Results: We found that the changes of local FCD (lFCD), not long-range FCD, of the left pre-/postcentral gyrus (Pre-/postCG), left superior temporal gyrus (STG), and right STG were significantly correlated with the changes of Hamilton Rating Scale for Depression (HRSD) scores in MDD patients before and after ECT. The subsequent functional connectivity analysis revealed significantly decreased functional connectivity between right STG and right intraparietal sulcus (IPS) in MDD after ECT in spite of no correlation with HRSD scores. Finally, SVM-based classification achieved an accuracy of 72.92% with a sensitivity of 73.91% and a specificity of 72% by leave-one-out cross-validation.Conclusions: Our findings indicated that Pre-/postCG and bilateral STG play an important role in response of ECT in MDD patients, and the lFCD in these areas may serve as a biomarker for predicting ECT response.