Endogenous and exogenous components in the circadian variation of core body temperature in humans
Endogenous and exogenous components in the circadian variation of core body temperature in humans
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DOI：
10.1046/j.1365-2869.1997.00047.x
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发表时间：
1997-09-01
影响因子：
4.4
通讯作者：
VandenHoofdakker, RH
中科院分区：
文献类型：
--
作者：
Hiddinga, AE;Beersma, DGM;VandenHoofdakker, RH
核心体温主要由内源性和外源性成分调节。在本研究中，我们测试了这两个组件是否可以可靠地评估在一个协议，持续时间只有120小时。在这个所谓的强制性脱暗方案中，12名健康男性受试者（年龄23.7 +/-1.4岁）逐一接受20小时的人工光/暗周期（10勒克斯与黑暗）。连续测量核心体温。基于内源性和外源性成分以相加方式对体温做出贡献的假设，通过迭代方法分析体温数据。结果表明，平均温度曲线几乎是两个组分的完美相加。内源性成分不同于正弦曲线，并且内源性和外源性成分对原始温度曲线的相对贡献在受试者之间显著不同。个体数据中无法解释的方差平均为17%。对受试者的体温曲线求平均值后，无法解释的方差仅为2%。在对受试者进行平均时无法解释的方差的这种减少一定是由于以下事实：大多数方差或者不同地依赖于各种受试者的昼夜节律相位，或者根本不依赖于昼夜节律相位。昼夜节律起搏成分显示tau的平均值为24.30 +/-0.36 h，这与文献中的最新发现一致。我们的结论是，一个简短的强制性的desperdy协议是足够的掩蔽和起搏器组件的核心体温之间的区别。同样的协议可以用来研究这些成分对其他各种生理和心理信号的影响。
Core body temperature is predominantly modulated by endogenous and exogenous components. In the present study we tested whether these two components can be reliably assessed in a protocol which lasts for only 120 h. In this so-called forced desynchrony protocol, 12 healthy male subjects (age 23.7 +/- 1.4 y) were subjected one by one to an artificial light/dark cycle of 20 h (10 lux vs. darkness). Core body temperature was measured continuously. The temperature data were analysed by an iterative method based on the assumption that the endogenous and exogenous components contribute to body temperature in an additive way. The results show that the average temperature curve is an almost perfect addition of the two components. The endogenous component differs from a sinusoid, and the relative contributions of the endogenous and exogenous components to the raw temperature curves differ substantially between the subjects. The average amount of unexplained variance in the individual data was 17%. Averaging of the body temperature curves over subjects reduced the unexplained variance to only 2%. This reduction in unexplained variance upon averaging over subjects must be due to the fact that most of the variance is either differently dependent on circadian phase for the various subjects or not dependent on circadian phase at all. The circadian pacemaker component revealed an average value of tau of 24.30 +/- 0.36 h, which is consistent with recent findings in the literature. We conclude that a short forced desynchrony protocol is sufficient for the distinction between the masking and pacemaker components of core body temperature. The same protocol can be used to study the influence of these components on all kinds of other physiological and psychological signals.