Effect of supplementation with vitamin E on LDL oxidizability and prevention of atherosclerosis
Effect of supplementation with vitamin E on LDL oxidizability and prevention of atherosclerosis
复制标题
补充维生素E对低密度脂蛋白氧化性和预防动脉粥样硬化的影响
DOI：
10.1002/biof.5520070108
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发表时间：
1998
期刊：
影响因子：
6
通讯作者：
H. Nakamura
中科院分区：
文献类型：
--
作者：
M. Suzukawa;M. Ayaori;H. Shige;T. Hisada;T. Ishikawa;H. Nakamura
补充低密度脂蛋白和维生素E被认为可以保护低密度脂蛋白免受氧化修饰，防止动脉粥样硬化的发展。大规模的流行病学研究表明，血浆中的维生素E水平与冠心病的发病率呈负相关。双盲安慰剂对照试验报告补充维生素E可降低冠心病患者的冠状动脉事件发生率。然而，目前还不清楚需要多高剂量的维生素E才能防止动脉粥样硬化的形成。在动物研究中，含有0.125%维生素E的饮食使血浆中维生素E的水平增加了一倍，并防止了高胆固醇血症兔胸主动脉早期动脉粥样硬化病变的形成。人体内的剂量反应研究报告称，每天400IU的维生素E使其血浆中的维生素E水平增加两倍，并延长了低密度脂蛋白氧化前的滞后时间。已有研究表明，冠心病患者低密度脂蛋白的氧化性与冠状动脉造影的动脉粥样硬化积分相关。每天大约400IU的维生素E将其水平提高两倍，并充分延长低密度脂蛋白氧化前的滞后时间，可能有助于降低个人患CHD的风险。
Supplementation of LDL with vitamin E is thought to protect LDL from oxidative modification and prevent the development of atherosclerosis. Large epidemiological studies have revealed that vitamin E levels in plasma are inversely correlated to the incidence of coronary heart disease. Double‐blind placebo‐controlled trials have reported that supplementation with vitamin E decreases the incidence of coronary events in coronary heart disease (CHD) patients. However, it is not clear how high a dose of vitamin E is needed to prevent formation of atherosclerosis. In animal studies, a diet containing 0.125% vitamin E increased its levels in plasma two‐fold and prevented formation of early atherosclerotic lesions in the thoracic aorta of hypercholesterolemic rabbits. Dose‐response studies in humans have reported that 400 IU/day vitamin E increased its levels in plasma two‐fold and prolonged the lag time before LDL oxidation. It has been reported that oxidizability of LDL was correlated to the atherosclerotic score of coronary angiography in CHD patients. About 400 IU/day vitamin E, which increases its levels two‐fold and prolongs sufficiently the lag time before LDL oxidation, might be beneficial in decreasing the individual risk of CHD.