Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates.
Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates.
复制标题
低剂量多巴胺对血压正常的极低出生体重新生儿尿量的影响。
DOI：
10.1038/jp.2013.20
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Wynn,JL
中科院分区：
文献类型：
--
作者：
Crouchley,JL;Smith,PB;Cotten,CM;Hornik,CD;Goldberg,RN;Foreman,JW;Wynn,JL
Objective:To determine the effects of low-dose dopamine on urine output (UOP) in very low birth weight premature neonates.Study Design:Retrospective cohort study of all low-dose (3–5 μg kg− 1 per min) dopamine infusions> 24-h duration in neonates⩽ 1500 g and⩽ 32 weeks gestation from August 2009 through September 2011. Linear regression was used to estimate the impact of covariates on UOP.Result:We identified 91 episodes of low-dose dopamine use in 65 neonates. Increased UOP occurred in 64% of episodes. Low-dose dopamine use was associated with a 0.6 ml kg− 1 h− 1 increase in UOP (P< 0.001) and a 1.3 ml kg− 1 h− 1 increase when baseline UOP was< 1.5 ml kg− 1 h− 1 (P< 0.001). The improvement remained statistically significant after controlling for medications (diuretics and hydrocortisone) and fluid intake.Conclusion:Low-dose dopamine use was associated with increased UOP in very low birth weight neonates.
