Incidence of primary opportunistic infections in two human immunodeficiency virus-infected French clinical cohorts.
Incidence of primary opportunistic infections in two human immunodeficiency virus-infected French clinical cohorts.
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两个人类免疫缺陷病毒感染的法国临床队列中原发性机会性感染的发生率。
DOI：
10.1093/ije/30.4.864
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发表时间：
2001
影响因子：
7.7
通讯作者：
Freedberg,KA
中科院分区：
文献类型：
--
作者：
Yazdanpanah,Y;Chêne,G;Losina,E;Goldie,SJ;Merchadou,LD;Alfandari,S;Seage3rd,GR;Sullivan,L;Marimoutou,C;Paltiel,AD;Salamon,R;Mouton,Y;Freedberg,KA
背景在美国收集的自然史数据的基础上，已经制定了预防人类免疫缺陷病毒（HIV）感染个体机会性感染的临床指南。本研究的目的是估计原发机会性感染的发病率在艾滋病毒感染的个人在地理上不同的coholsinFrance.MethodsWe进行了我们的研究2664艾滋病毒感染的患者从图尔昆艾滋病参考中心和医院-1987年1月至1995年9月在阿基坦SIDA临床流行病学小组的信息系统中登记，1995年12月我们估计：（1）CD 4-调整的发病率的七个主要机会性感染的预防，具体的感染或任何抗逆转录病毒药物以外的齐多夫定;和（2）CD 4淋巴细胞计数declined.ResultsThe最高发病率的所有机会性感染的研究发生在患者的CD 4计数<200/μl。当CD 4计数<50/μl时，最常见的机会性感染是弓形虫脑炎（12.6/100人年）和卡氏肺孢子虫（11.4/100人年），最不常见的机会性感染是结核分枝杆菌（<5.0/100人年）。即使CD 4计数>300/μl，仍有卡氏肺孢子虫和弓形体脑炎病例报告。每月平均CD 4淋巴细胞下降为4.6个细胞/μl。HIV危险行为与巨细胞病毒感染的发病率之间、日历年与卡氏肺孢子虫、弓形体脑炎和念珠菌性食管炎的发病率之间、地理区域与卡氏肺孢子虫和巨细胞病毒感染的发病率之间存在显著相关性。这些结果可用于确定当地预防机会性感染的优先事项。
BackgroundClinical guidelines for the prevention of opportunistic infections in human immunodeficiency virus (HIV)-infected individuals have been developed on the basis of natural history data collected in the USA. The objective of this study was to estimate the incidence of primary opportunistic infections in HIV-infected individuals in geographically distinct cohorts in France.MethodsWe conducted our study on 2664 HIV-infected patients from the Tourcoing AIDS Reference Centre and the hospital-based information system of the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine enrolled from January 1987 to September 1995 and followed through December 1995. We estimated: (1) CD4-adjusted incidence rates of seven primary opportunistic infections in the absence of prophylaxis for that specific infection or any antiretroviral drugs other than zidovudine; and (2) CD4 lymphocyte count decline.ResultsThe highest incidence rates for all opportunistic infections studied occurred in patients with CD4 counts <200/μl. With CD4 counts <50/μl, the most common opportunistic infections were toxoplasmic encephalitis (12.6 per 100 person-years) andPneumocystis cariniipneumonia (11.4 per 100 person-years).Mycobacterium tuberculosiswas the least common opportunistic infection (<5.0/100 person-years). Even with CD4 counts >300/μl, cases ofPneumocystis cariniipneumonia and toxoplasmic encephalitis were reported. The mean CD4 lymphocyte decline per month was 4.6 cells/μl. There was a significant association between HIV risk behaviour and the incidence of cytomegalovirus infection, between calendar year and the incidence ofPneumocystis cariniipneumonia, toxoplasmic encephalitis andCandida esophagitis, and between geographical area and the incidence ofPneumocystis cariniipneumonia and cytomegalovirus infection.ConclusionsGeographical differences exist in the incidence of HIV-related opportunistic infections. These results can be used to define local priorities for prophylaxis of opportunistic infections.
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新英格兰医学杂志 在接受联合抗逆转录病毒治疗的 HIV-1 感染成人中停止卡氏肺囊虫肺炎的一级预防
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
N. Pakker;M. Roos;R. van Leeuwen;M. D. de Jong;M. Koot;P. Reiss;J. Lange;F. Miedema;S. Danner;P. Schellekens
通讯作者：
P. Schellekens
获得性免疫缺陷综合征（艾滋病）40例中枢神经系统病理分析
影响因子：
5
作者：
F. Gray;R. Gherardi;C. Keohane;M. Favolini;A. Sobel;J. Poirier
通讯作者：
J. Poirier
影响因子：
3.8
作者：
CHAN, ISF;NEATON, JD;OSTERBERGER, J
通讯作者：
OSTERBERGER, J
CD4 细胞计数 < 100/mm3 的同性恋男性队列中临床艾滋病状况的发病率。
DOI：
10.1093/infdis/170.5.1284
发表时间：
1994
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Bacellar,H;Muñoz,A;Hoover,DR;Phair,JP;Besley,DR;Kingsley,LA;Vermund,SH
通讯作者：
Vermund,SH
DOI：
10.1097/00005072-198611000-00003
发表时间：
1986-11-01
影响因子：
3.2
作者：
PETITO, CK;CHO, ES;PRICE, RW
通讯作者：
PRICE, RW