Regulation of let-7 and its target oncogenes (Review)
Regulation of let-7 and its target oncogenes (Review)
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let-7 及其靶癌基因的调控（综述）
DOI：
10.3892/ol.2012.609
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发表时间：
2012-05-01
期刊：
影响因子：
2.9
通讯作者：
You, Yongping
中科院分区：
文献类型：
--
作者：
Wang, Xirui;Cao, Lei;You, Yongping
MicroRNAs(MiRNAs)是进化高度保守的非编码小RNA，最先在秀丽线虫中发现。Let-7miRNA参与细胞内基因表达的调控。一些新的因子和反馈环参与了对let-7合成的调控，并发现了更多的let-7靶基因。Let-7也被证明与癌症的发生和发展密切相关，初步研究结果表明，它参与了多种类型肿瘤的致癌途径的调节。因此，let-7是肿瘤治疗的潜在分子靶点。因此，本综述研究了let-7以及let-7与癌症致癌途径之间的相关性。
MicroRNAs (miRNAs) are highly evolutionarily-conserved non-coding small RNAs, which were first identified in Caenorhabditis elegans. Let-7 miRNA is involved in the regulation of gene expression in cells. Several novel factors and feedback loops involved in the regulation of the synthesis of let-7 have been identified and additional let-7 target genes have been found. Let-7 has also been shown to be significantly correlated with the occurrence and development of cancer and the results of preliminary studies suggest that it is involved in the regulation of oncogenic pathways in numerous types of tumors. Let-7 is, therefore, a potential molecular target for tumor therapy. Thus, this review examined let-7 and the correlation between let-7 and oncogenic pathways in cancer.