Microchimerism and the pathogenesis of systemic sclerosis
Microchimerism and the pathogenesis of systemic sclerosis
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DOI：
10.1097/00002281-199811000-00010
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发表时间：
1998-11-01
影响因子：
5.1
通讯作者：
Nelson, J. Lee
中科院分区：
文献类型：
--
作者：
Nelson, J. Lee
分子生物学技术在人类妊娠研究中的应用导致了胎儿-母体界面双向细胞交通的认识。研究发现，胎儿祖细胞在分娩后数十年仍存留在母体外周血中。硬皮病对女性有很强的好发性，在育龄后的女性中发病率最高，其临床与同种异体干细胞移植后发生的慢性移植物抗宿主病相似。本文探讨了微嵌合现象导致硬皮病发病机制的假设，并回顾了支持该假设的早期研究。嵌合现象用于表示一个身体含有来自不同个体的细胞群；微嵌合表示低水平的嵌合。微嵌合可能导致硬皮病发病机制的机制尚不清楚，但可以通过移植生物学中微嵌合研究中获得的知识获得见解。尽管微嵌合现象在硬皮病研究中得到了强调，但微嵌合现象也与某些其他自身免疫性疾病有关。
The application of molecular biological techniques to the study of human pregnancy has resulted in the recognition of bidirectional cell traffic at the fetal-maternal interface. Fetal progenitor cells have been found to persist in the maternal peripheral blood for decades after childbirth. Scleroderma has a strong predilection for women, a peak incidence in women following childbearing years, and clinical similarities to chronic graftversus-host disease that occurs after allogeneic stem cell transplantation. This article explores the hypothesis that microchimerism contributes to the pathogenesis of scleroderma and reviews early studies that lend support to this hypothesis. Chimerism is used to indicate a body that contains cell populations derived from different individuals; microchimerism indicates low levels of chimerism. A mechanism by which microchimerism might contribute to the pathogenesis of scleroderma is unknown, but insights can be gained through knowledge garnered in studies of microchimerism in transplantation biology. Although highlighted in the study of scleroderma, microchimerism is also implicated in selected other autoimmune disorders.