Analysis for gene networks based on logic relationships
Analysis for gene networks based on logic relationships
复制标题
基于逻辑关系的基因网络分析
DOI：
10.1007/s11424-010-0205-0
复制
发表时间：
2010-10-01
影响因子：
2.1
通讯作者：
Meng, Dazhi
中科院分区：
文献类型：
--
作者：
Wang, Shudong;Chen, Yan;Meng, Dazhi
分子相互作用网络的逆向构建和分析对于理解它们在细胞内的功能至关重要。本文构建了一个逻辑网络模型来研究拟南芥地上部基因响应刺激的复杂调控机制。对复杂逻辑网络的动力学进行了分析、讨论和仿真。模拟结果表明，地上部活性基因的逻辑网络在刺激下最终演化为11个吸引子，其中包括5个1周期吸引子和6个2周期吸引子。我们的工作为生物学家通过实验理解和解释拟南芥对外界刺激的反应提供了有价值的参考和指导。
The reverse construction and analysis of the networks of molecular interactions are essential for understanding their functions within cells. In this paper, a logic network model is constructed to investigate the complicated regulation mechanism of shoot genes of Arabidopsis Thaliana in response to stimuli. The dynamics of the complicated logic network is analyzed, discussed, and simulated. The simulation results show that the logic network of the active genes of shoot eventually evolves into eleven attractors under the stimuli, including five 1-periodic and six 2-periodic attractors. Our work provides valuable reference and guidance for biologists to understand and explain Arabidopsis' response to external stimuli by experiments.