Differential in vivo and in vitro HLA-G expression in melanoma cells:: Potential mechanisms
Differential in vivo and in vitro HLA-G expression in melanoma cells:: Potential mechanisms
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DOI：
10.1016/j.humimm.2003.08.357
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发表时间：
2003-11-01
期刊：
影响因子：
2.7
通讯作者：
Ferrone, S
中科院分区：
文献类型：
--
作者：
Chang, CC;Murphy, SP;Ferrone, S
人白细胞抗原G （HLA-G）在肿瘤免疫逃逸中的潜在作用激发了对该分子在恶性细胞中的表达分析的兴趣。在黑色素瘤中，分别约30%和不到1%的手术切除病变和培养细胞系表达HLA-G蛋白。HLA-G表达频率显著差异的原因尚不清楚。在这里，我们讨论了HLA-G检测方法、肿瘤微环境中的应激因素以及肿瘤进展过程中表观遗传变化在黑色素瘤细胞体内和体外HLA-G表达差异中的潜在作用。我们提出了一个可能解释黑色素瘤细胞中HLA-G在体内优先表达的模型。如果被证明是正确的，该模型为研究黑色素瘤细胞中调节HLA-G表达的机制以及制定对抗黑色素瘤患者HLA-G表达的策略提供了有用的背景。人类免疫学64,1057-1063（2003）。(C)美国组织相容性与免疫遗传学学会，2003。Elsevier Inc.出版。
The potential role of human leukocyte antigen G (HLA-G) in tumor immune escape has stimulated interest in the analysis of the expression of this molecule in malignant cells. In melanoma approximately 30% and less than 1% of surgically-removed lesions and cultured cell lines, respectively, have been found to express HLA-G protein. The reason for the marked difference in HLA-G expression frequency is unknown. Here we discuss the potential role of HLA-G detection methodology, stress factors in the tumor microenvironment, and epigenetic changes during tumor progression in the differential in vivo and in vitro HLA-G expression in melanoma cells. We propose a model that may account for the preferential in vivo HLA-G expression in melanoma cells. If proven correct, this model represents a useful background to investigate the mechanisms regulating HLA-G expression in melanoma cells and to devise strategies to counteract HLA-G expression in patients with melanoma. Human Immunology 64, 1057-1063 (2003). (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc.