Clinical advances in oncolytic virotherapy for pediatric brain tumors.
Clinical advances in oncolytic virotherapy for pediatric brain tumors.
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DOI：
10.1016/j.pharmthera.2022.108193
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发表时间：
2022-11
影响因子：
13.5
通讯作者：
Friedman, Gregory K.
中科院分区：
文献类型：
--
作者：
Ghajar-Rahimi, Gelare;Kang, Kyung-Don;Totsch, Stacie K.;Gary, Sam;Rocco, Abbey;Blitz, Sarah;Kachurak, Kara;Chambers, M. R.;Li, Rong;Beierle, Elizabeth A.;Bag, Asim;Johnston, James M.;Markert, James M.;Bernstock, Joshua D.;Friedman, Gregory K.
恶性脑肿瘤占儿童癌症诊断的近三分之一，最近已超过血液恶性肿瘤，成为儿科人群中最致命的肿瘤。脑肿瘤患儿的预后差得令人无法接受，目前的治疗标准--手术切除、化疗和放疗--与显著的长期发病率相关。溶瘤病毒疗法已成为治疗脑肿瘤的一种有前途的免疫疗法。虽然大多数使用溶瘤病毒疗法的脑肿瘤临床试验是在成人中进行的，但在儿科脑肿瘤临床试验中正在测试五种病毒：单纯疱疹病毒（G207）、呼肠孤病毒（pelareorep/Reolysin）、麻疹病毒（MV-NIS）、脊髓灰质炎病毒（PVSRIPO）和腺病毒（DNX-2401，AloCELYVIR）。在此，我们回顾了过去和目前的儿科脑肿瘤免疫病毒治疗试验，包括相关的临床前和临床研究，有助于他们的发展。我们描述了病毒可能克服治疗小儿脑肿瘤障碍的机制，研究了与实现有效，持久反应相关的挑战，强调了试验的独特方面和成功，并讨论了免疫病毒治疗研究治疗小儿脑肿瘤的未来方向。
Malignant brain tumors constitute nearly one-third of cancer diagnoses in children and have recently surpassed hematologic malignancies as the most lethal neoplasm in the pediatric population. Outcomes for children with brain tumors are unacceptably poor and current standards of care—surgical resection, chemotherapy, and radiation—are associated with significant long-term morbidity. Oncolytic virotherapy has emerged as a promising immunotherapy for the treatment of brain tumors. While the majority of brain tumor clinical trials utilizing oncolytic virotherapy have been in adults, five viruses are being tested in pediatric brain tumor clinical trials: herpes simplex virus (G207), reovirus (pelareorep/Reolysin), measles virus (MV-NIS), poliovirus (PVSRIPO), and adenovirus (DNX-2401, AloCELYVIR). Herein, we review past and current pediatric immunovirotherapy brain tumor trials including the relevant preclinical and clinical research that contributed to their development. We describe mechanisms by which the viruses may overcome barriers in treating pediatric brain tumors, examine challenges associated with achieving effective, durable responses, highlight unique aspects and successes of the trials, and discuss future directions of immunovirotherapy research for the treatment of pediatric brain tumors.
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影响因子：
11.2
作者：
Galanis E;Atherton PJ;Maurer MJ;Knutson KL;Dowdy SC;Cliby WA;Haluska P Jr;Long HJ;Oberg A;Aderca I;Block MS;Bakkum-Gamez J;Federspiel MJ;Russell SJ;Kalli KR;Keeney G;Peng KW;Hartmann LC
通讯作者：
Hartmann LC
影响因子：
21.3
作者：
Farassati, F;Yang, AD;Lee, PWK
通讯作者：
Lee, PWK
影响因子：
4.6
作者：
Castro MG;Candolfi M;Wilson TJ;Calinescu A;Paran C;Kamran N;Koschmann C;Moreno-Ayala MA;Assi H;Lowenstein PR
通讯作者：
Lowenstein PR
影响因子：
4.2
作者：
通讯作者：
--
影响因子：
4.6
作者：
Friedman GK;Bernstock JD;Chen D;Nan L;Moore BP;Kelly VM;Youngblood SL;Langford CP;Han X;Ring EK;Beierle EA;Gillespie GY;Markert JM
通讯作者：
Markert JM