Trihydroxylated linear diterpenes from the brown alga Bifurcaria bifurcata
Trihydroxylated linear diterpenes from the brown alga Bifurcaria bifurcata
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DOI：
10.1016/j.phytochem.2004.03.014
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发表时间：
2004-07-01
期刊：
影响因子：
3.8
通讯作者：
Piovetti, L
中科院分区：
文献类型：
--
作者：
Culioli, G;Ortalo-Magné, A;Piovetti, L
从采自摩洛哥大西洋沿岸的棕色二叉果中分离得到两个新的极性二萜化合物，并通过波谱方法确定了它们的结构。两种化合物均为衍生自12-羟基香叶基香叶醇的三羟基化无环二萜。在体外测试它们的细胞毒性，并证明它们对NSCLC-N6细胞系具有活性。它们在C-12位的绝对构型已经用改进的Mosher方法测定[J. Am. 113（1991）4092]和12-羟基香叶基香叶醇（bifurcadiol）的结构进行了修订。(C)2004爱思唯尔有限公司保留所有权利。
Two novel polar diterpenes were isolated from the brown alga Bifurccaria bifurcata collected off the Atlantic coast of Morocco, and their structures established by spectral methods. Both compounds are trihydroxylated acyclic diterpenes derived from 12-hydroxygeranylgeraniol. They were tested in vitro for their cytotoxicity and proved to be active against the NSCLC-N6 cell line. Their absolute configuration at the C-12 position has been determined with a modified Mosher's method [J. Am. Chem. Soc. 113 (1991) 4092] and that of the 12-hydroxygeranylgeraniol (bifurcadiol) has been revised. (C) 2004 Elsevier Ltd. All rights reserved.