Hybrid 10 clinical trial: preliminary results.
Hybrid 10 clinical trial: preliminary results.
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DOI：
10.1159/000206493
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发表时间：
2009
影响因子：
1.6
通讯作者：
Parkinson AJ
中科院分区：
文献类型：
--
作者：
Gantz BJ;Hansen MR;Turner CW;Oleson JJ;Reiss LA;Parkinson AJ
声学加电（电声）语音处理已成功地强调了发音信息在那些频率大于 1500 Hz 且辨别分数低于 60% 的高频听力损失的成年人的辅音识别中的重要作用。八十七名受试者参加了一项成人混合多中心食品和药物管理局临床试验。 85/87 的受试者立即实现了听力保留。随着时间的推移（3个月到5年），91%的人保持了一定程度的听力保留。与术前佩戴双侧助听器的听力相比，电声处理相结合使这组志愿者中的大多数人获得了更好的言语理解能力。大多数人的低频听力保留在术前纯音水平 15 dB 以内。那些损耗较大（> 30 dB）的也受益于电声语音处理的结合。术后，在电声处理条件下，低频听力的丧失与安静时言语感知得分的改善并不相关。十六名受试者被确定为表现不佳，因为他们没有通过电声处理实现显着改善。多元回归分析确定，表现不佳组中 91% 的方差可以通过术前语音识别评分和耳聋持续时间来解释。在电声处理条件下，某些个体在噪声中的语音理解信噪比提高了 9 dB 以上。噪声阈值中的语音理解与残余低频声学听力之间的关系显着（r = 0.62；p < 0.05）。数据表明，一般来说，除非听力损失达到严重程度，否则通过保留残余听力来进行噪声中的语音识别所获得的优势是存在的。在扩大标准人工耳蜗植入候选人的选择标准时，应考虑保留残余低频听力。在确定混合植入物的选择标准时，严重高频听力损失的持续时间似乎是一个重要变量。
Acoustic plus electric (electric-acoustic) speech processing has been successful in highlighting the important role of articulation information in consonant recognition in those adults that have profound high-frequency hearing loss at frequencies greater than 1500 Hz and less than 60% discrimination scores. Eighty-seven subjects were enrolled in an adult Hybrid multicenter Food and Drug Administration clinical trial. Immediate hearing preservation was accomplished in 85/87 subjects. Over time (3 months to 5 years), some hearing preservation was maintained in 91% of the group. Combined electric-acoustic processing enabled most of this group of volunteers to gain improved speech understanding, compared to their preoperative hearing, with bilateral hearing aids. Most have preservation of low-frequency acoustic hearing within 15 dB of their preoperative pure tone levels. Those with greater losses (> 30 dB) also benefited from the combination of electric-acoustic speech processing. Postoperatively, in the electric-acoustic processing condition, loss of low-frequency hearing did not correlate with improvements in speech perception scores in quiet. Sixteen subjects were identified as poor performers in that they did not achieve a significant improvement through electric-acoustic processing. A multiple regression analysis determined that 91% of the variance in the poorly performing group can be explained by the preoperative speech recognition score and duration of deafness. Signal-to-noise ratios for speech understanding in noise improved more than 9 dB in some individuals in the electric-acoustic processing condition. The relation between speech understanding in noise thresholds and residual low-frequency acoustic hearing is significant (r = 0.62; p < 0.05). The data suggest that, in general, the advantages gained for speech recognition in noise by preserving residual hearing exist, unless the hearing loss approaches profound levels. Preservation of residual low-frequency hearing should be considered when expanding candidate selection criteria for standard cochlear implants. Duration of profound high-frequency hearing loss appears to be an important variable when determining selection criteria for the Hybrid implant.
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影响因子：
1.6
作者：
Gfeller, Kate E;Olszewski, Carol;Oleson, Jacob
通讯作者：
Oleson, Jacob
影响因子：
2.6
作者：
Gantz, BJ;Turner, C;Lowder, MW
通讯作者：
Lowder, MW
影响因子：
2.4
作者：
Hogan, CA;Turner, CW
通讯作者：
Turner, CW
影响因子：
1.4
作者：
Gantz, BJ;Turner, C
通讯作者：
Turner, C
DOI：
10.1007/s10162-007-0077-8
发表时间：
2007-06-01
影响因子：
2.4
作者：
Reiss, Lina A. J.;Turner, Christopher W.;Gantz, Bruce J.
通讯作者：
Gantz, Bruce J.