Simple Assessment of Cerebral Hemodynamics Using Single-Slab 3D Time-of-Flight MR Angiography in Patients with Cervical Internal Carotid Artery Steno-Occlusive Diseases: Comparison with Quantitative Perfusion Single-Photon Emission CT
Simple Assessment of Cerebral Hemodynamics Using Single-Slab 3D Time-of-Flight MR Angiography in Patients with Cervical Internal Carotid Artery Steno-Occlusive Diseases: Comparison with Quantitative Perfusion Single-Photon Emission CT
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DOI：
10.3174/ajnr.a1389
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发表时间：
2009-03-01
影响因子：
3.5
通讯作者：
Ogawa, A.
中科院分区：
文献类型：
--
作者：
Hirooka, R.;Ogasawara, K.;Ogawa, A.
背景与目的：单平板三维飞行时间（TOF） MR血管造影（MRA）显示外周动脉可以反映血流速度。大脑中动脉（MCA）流速可能与脑血管对乙酰唑胺的反应性（CVR）相关，可用于评估血流动力学损伤。本研究的目的是比较MRA上MCA的信号强度与灌注单光子发射CT （SPECT）量化的CVR。材料与方法：根据对87例单侧或双侧颈内动脉（ICA）狭窄闭塞性疾病患者的108个大脑半球MCA的可视化能力，对单侧或双侧颈内动脉（ICA）狭窄闭塞性疾病患者的单侧或双侧大脑半球MCA的信号强度进行分级。SPECT-CVR也通过测量乙酰唑胺刺激前后的脑血流量来计算。以10名健康受试者为研究对象，获得对照SPECT-CVR值。所有受试者在研究前都提供了书面知情同意书。结果：脑中动脉信号强度降低的大脑半球CVR明显低于正常脑中动脉信号强度组(P
BACKGROUND AND PURPOSE: Visualization of the peripheral arteries on single-slab 3D time-of-flight (TOF) MR angiography (MRA) can reflect blood flow velocity. The velocity in the middle cerebral artery (MCA) may correlate with cerebrovascular reactivity (CVR) to acetazolamide, which can be used to assess hemodynamic impairment. The goal of this study was to compare the signal intensity of the MCA on MRA versus CVR quantified by perfusion single-photon emission CT (SPECT).MATERIALS AND METHODS: The signal intensity of the MCA on single-slab 3D time-of-flight MRA was graded according to the ability to visualize the MCA in 108 cerebral hemispheres of 87 patients with unilateral or bilateral cervical internal carotid artery (ICA) steno-occlusive diseases. SPECT-CVR was also calculated by measuring cerebral blood flow before and after acetazolamide challenge. Ten healthy subjects were studied to obtain control SPECT-CVR values. All subjects provided written informed consent before the study.RESULTS: CVR was significantly lower in cerebral hemispheres with reduced MCA signal intensity than in those with normal intensity (P