Estradiol fatty acid esters occur naturally in human blood.
Estradiol fatty acid esters occur naturally in human blood.
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雌二醇脂肪酸酯天然存在于人体血液中。
DOI：
10.1126/science.6419346
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Hochberg,RB
中科院分区：
文献类型：
--
作者：
Janocko,L;Hochberg,RB
用弱碱处理人类女性血液的非极性醚提取物比未水解的提取物产生更多的免疫测定雌二醇。血清提取物的分析表明，水解后释放免疫反应性雌二醇的物质具有与在碳17酯化的雌二醇脂肪酸酯相同的色谱特性。这些以前未知的内源性酯的生理作用可能是推断从其结构相似的合成药物用于治疗其延长雌激素作用。
Treatment of nonpolar ether extracts of human female blood with mild alkali produced more immunoassayable estradiol than the unhydrolyzed extract. Analysis of the serum extracts showed that the substance which released immunoreactive estradiol after hydrolysis has chromatographic properties identical to those of fatty acid esters of estradiol esterified at carbon 17. The physiological role of these previously unknown endogenous esters might be inferred from their structural similarity to synthetic drugs used therapeutically for their prolonged estrogenic action.