Epigenetic basis for the development of depression in children.
Epigenetic basis for the development of depression in children.
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DOI：
10.1097/grf.0b013e318299d2a8
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发表时间：
2013-09
影响因子：
1.5
通讯作者：
Marsit CJ
中科院分区：
文献类型：
--
作者：
Lester BM;Conradt E;Marsit CJ
表观遗传学和人类行为领域的发展为发现精神健康障碍的分子基础提供了前所未有的机会，并为预防干预计划的发展铺平了道路。母亲在怀孕期间抑郁是一个严重的公共卫生问题，导致儿童患抑郁症的可能性增加四倍。我们描述了情绪障碍，特别是抑郁症，可能是由早期生活压力、编程和表观遗传过程和途径形成的，并展示了这些过程如何导致儿童时期的抑郁症。讨论了这种方法对精神健康障碍预防干预研究的意义。
The growing field of epigenetics and human behavior affords an unprecedented opportunity to discover molecular underpinnings of mental health disorders and pave the way for the development of preventive intervention programs. Maternal depression during pregnancy is a serious public health issue and leads to a fourfold increase in the likelihood that the child will develop depression. We describe how mood disorders, particularly depression, may be shaped by early life stress, programming, and epigenetic processes and pathways showing how these processes could lead to depression in childhood. Implications of this approach to the study of mental health disorders for preventive interventions are discussed.