Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration in a Pig Model.
Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration in a Pig Model.
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磷酸化支链淀粉涂层可增强猪模型中钛种植体的骨整合。
DOI：
10.11607/jomi.5074
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Duyck J.
中科院分区：
文献类型：
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作者：
Cardoso MV;Chaudhari A;Yoshihara K;Mesquita MF;Yoshida Y;Van Meerbeek B;Vandamme K;Duyck J.
目的：研究磷酸化多糖普鲁兰多糖涂层钛种植体表面对种植体周围骨形成和种植体骨结合的影响。材料与方法：将种植体植入12只家猪颅骨内，愈合1 ~ 3个月。通过定量组织学（种植体周围骨分数[BF]和骨-种植体接触[BIC]）评价（未）涂层种植体的骨整合。Wilcoxon-Mann-Whitney检验，α=。05用于统计学比较涂层和未涂层植入物的BF和BIC。结果：与未涂层种植体相比，普鲁兰多糖涂层种植体周围的BF明显增多（P <0. 05）。05)两个愈合期组均P <. 05）。BIC受到胞外多糖涂层的积极影响，与未涂层种植体相比，3个月愈合期后BIC显著增加（P <. 05）。此外，随着时间的推移，涂层种植体的BIC保持稳定，而未涂层种植体的BIC显著降低（P <. 05）。结论：这些发现揭示了用磷酸化普鲁兰多糖使钛种植体表面功能化以改善种植体-骨界面矿化的能力。
Purpose: To investigate the effect of coating a titanium implant surface with a phosphorylated exopolysaccharide, pullulan, on the peri-implant bone formation and implant osseointegration. Materials and Methods: Implants were placed in the skull bone of 12 domestic pigs and healed for 1 or 3 months. Osseointegration of (un) coated implants was evaluated by quantitative histology (peri-implant bone fraction [BF] and bone-to-implant-contact [BIC]). The Wilcoxon-Mann-Whitney test with α=. 05 was used to statistically compare BF and BIC of the coated and uncoated implants. Results: Significantly more BF was observed surrounding pullulan-coated implants compared with uncoated implants (P <. 05) and for both healing periods (P <. 05). BIC was positively affected by the exopolysaccharide coating, with significantly more BIC after the 3-month healing period compared with the uncoated implant (P <. 05). Furthermore, BIC remained stable over time for the coated implants, while it significantly decreased for the uncoated ones (P <. 05). Conclusion: These findings reveal the capacity of functionalizing the titanium implant surface with phosphorylated pullulan to improve the mineralization of the implant-bone interface.