Dynamic Imine Chemistry at Complex Double Emulsion Interfaces
Dynamic Imine Chemistry at Complex Double Emulsion Interfaces
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DOI：
10.1021/jacs.9b06852
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发表时间：
2019-11-13
影响因子：
15
通讯作者：
Swager, Timothy M.
中科院分区：
文献类型：
--
作者：
Zentner, Cassandra A.;Anson, Francesca;Swager, Timothy M.
界面化学提供了控制动态材料的机会。通过利用亚胺键的动态共价性质，乳液原位生成，可预测地操纵，并最终通过亚胺平衡的简单扰动沿着液体液体和乳液固体界面被破坏。我们报道了通过在油/水的液液界面自发地原位形成亚胺来快速生产表面活性剂和双乳液。含有亚胺表面活性剂的复合双乳液在中性和碱性条件下稳定，并通过酸催化水解和亚胺交换表现出动态行为。我们证明了原位亚胺表面活性剂形成与生物分子（即抗体）形成复合表面活性剂用于生物传感应用的潜力。此外，乳液-固体界面处的亚胺形成提供了触发的有效负载释放机制。我们的结果说明了简单的动态界面亚胺形成如何将键合变化转化为宏观输出。
Interfacial chemistry provides an opportunity to control dynamic materials. By harnessing the dynamic covalent nature of imine bonds, emulsions are generated in situ, predictably manipulated, and ultimately destroyed along liquid liquid and emulsion solid interfaces through simple perturbation of the imine equilibria. We report the rapid production of surfactants and double emulsions through spontaneous in situ imine formation at the liquid liquid interface of oil/water. Complex double emulsions with imine surfactants are stable to neutral and basic conditions and display dynamic behavior with acid-catalyzed hydrolysis and imine exchange. We demonstrate the potential of in situ imine surfactant formation to generate complex surfactants with biomolecules (i.e., antibodies) for biosensing applications. Furthermore, imine formation at the emulsion-solid interface offers a triggered payload release mechanism. Our results illustrate how simple, dynamic interfacial imine formation can translate changes in bonding to macroscopic outputs.