Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease
Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease
复制标题
DOI：
10.1093/qjmed/hcp057
复制
发表时间：
2009-07-01
影响因子：
13.3
通讯作者：
Walker, B. R.
中科院分区：
文献类型：
--
作者：
Reynolds, R. M.;Ilyas, B.;Walker, B. R.
目的：探讨循环皮质醇水平对冠状动脉病变或周围血管病变的预测作用。方法：对278例疑似冠心病患者、76例有周围血管病变患者和85例无周围血管病变患者的基础血浆皮质醇水平进行检测。结果：在调整潜在的混杂因素后，冠状动脉造影术确诊的冠心病患者和冠状动脉造影术后需要干预的患者的血浆皮质醇水平均呈下降趋势(P=0.10)。皮质醇水平降低也预示着有更多心绞痛症状的人(P=0.01)。皮质醇水平在有或无外周血管疾病的患者中没有差别。结论：循环皮质醇的单一测量不能很好地预测血管疾病。有必要对HPA轴进行更详细的描述，以确定循环中内源性糖皮质激素的作用及其在动脉粥样硬化中对应激的反应。
Aims: To determine whether basal circulating cortisol levels predict coronary artery (CAD) or peripheral vascular disease.Methods: Basal plasma cortisol levels were measured in 278 subjects with suspected CAD, who had undergone elective coronary angiography and in 76 cases and 85 controls with and without peripheral vascular disease, respectively.Results: After adjustment for potential confounding factors, circulating cortisol levels tended to be lower in those with confirmed coronary vessel disease at angiography (P = 0.10), and in those requiring intervention following angiography (P = 0.07). Lower cortisol levels also predicted those with more symptoms of angina (P = 0.01). Cortisol levels were no different in those with or without peripheral vascular disease.Conclusion: A single measurement of circulating cortisol is a poor predictor of vascular disease. More detailed characterization of the HPA axis is necessary to determine the role of circulating endogenous glucocorticoids and their responsiveness to stress in atherosclerosis.