Allergic rhinitis in adolescence increases the risk of depression in later life: A nationwide population-based prospective cohort study
Allergic rhinitis in adolescence increases the risk of depression in later life: A nationwide population-based prospective cohort study
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DOI：
10.1016/j.jad.2012.07.011
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发表时间：
2013-02-15
影响因子：
6.6
通讯作者：
Bai, Ya-Mei
中科院分区：
文献类型：
--
作者：
Chen, Mu-Hong;Su, Tung-Ping;Bai, Ya-Mei
背景：许多横断面研究表明变应性鼻炎（AR）与抑郁之间存在关联，但时间关系尚未确定。通过一项基于全国人群的前瞻性队列研究（1:4，年龄/性别匹配），我们假设青春期AR会增加以后生活中抑郁的风险。方法：在我们的研究中，共招募了1673名在1996年至2000年间患有AR的12-15岁青少年。在随访结束时（2010年12月31日）发现重度抑郁症和任何抑郁症病例。结果：与对照组相比，AR青少年有更高的重度抑郁症患病率（2.5% vs. 1.2%, p < 0.001）和任何抑郁症（4.9% vs. 2.8%, p < 0.001），并且更早发病的重度抑郁症（19.31 +/- 2.91 vs. 20.43 +/- 2.71年，p = 0.038）和任何抑郁症（19.35 +/- 2.63 vs. 20.43 +/- 2.62年，p = 0.002）。Cox回归模型显示，在控制居住地和共病过敏性疾病后，AR青少年的重性抑郁（HR: 1.59,95% CI: 1.02-2.50）和任何抑郁障碍（HR: 1.42, 95% CI: 1.04-1.93）的HR增加。局限性：抑郁症的患病率可能被低估了，因为只有那些有求医行为的人被纳入研究。结论：这项首次队列病例对照研究显示，青春期早期的AR与青春期晚期和成年早期的抑郁之间存在关联。我们的研究结果表明，过敏反应在抑郁症的发展中起着重要作用。(C) 2012 Elsevier B.V.版权所有
Background: Many cross-sectional studies have suggested an association between allergic rhinitis (AR) and depression, but the timing relationship was not determined. Using a nationwide population-based prospective cohort study (1:4, age-/gender-matched), we hypothesized that AR in adolescence would increase the risk of depression in later life.Methods: In all, 1673 adolescents aged 12-15 that had AR between 1996 and 2000 were recruited for our study. Cases of major depressive disorder and any depressive disorder that occurred to the end of follow-up (December 31, 2010) were identified.Result: Adolescents with AR had a higher prevalence of major depression (2.5% vs. 1.2%, p < 0.001) and any depressive disorder (4.9% vs. 2.8%, p < 0.001) and an earlier onset of major depression (19.31 +/- 2.91 vs. 20.43 +/- 2.71 years, p = 0.038) and any depressive disorder (19.35 +/- 2.63 vs. 20.43 +/- 2.62 years, p = 0.002) compared with the controls. The Cox regression model showed that adolescents with AR had increased HRs of major depression (HR: 1.59,95% CI: 1.02-2.50) and any depressive disorder (HR: 1.42, 95% CI: 1.04-1.93) after controlling residence location and comorbid allergic diseases.Limitations: The prevalence of depressive disorder may be underestimated because only those who had medicine-seeking behaviors were enrolled.Conclusions: This first cohort case-control study showed an association between AR in early adolescence and depression in late adolescence and early adulthood. Our results suggested that allergic responses played important roles in the development of depression. (C) 2012 Elsevier B.V. All rights reserved.