p-Fluoro-hexahydro-sila-difenidol: affinity for vascular muscarinic receptors.
p-Fluoro-hexahydro-sila-difenidol: affinity for vascular muscarinic receptors.
复制标题
对氟-六氢-硅拉-地芬尼多：对血管毒蕈碱受体的亲和力。
DOI：
10.1016/0014-2999(90)90645-m
复制
发表时间：
1990
影响因子：
5
通讯作者：
Duckles,SP
中科院分区：
文献类型：
--
作者：
Duckles,SP
m3选择性拮抗剂对氟六氢硅氧烷二苯醚被用来表征两种血管制剂中的毒毒碱受体，具有内皮依赖性松弛的兔耳动脉和具有内皮依赖性收缩反应的牛冠状动脉。pkb值与m3受体的存在一致，冠状动脉和耳动脉分别为7.9和7.5。这些发现证实兔耳动脉和牛冠状动脉的毒蕈碱受体具有相似的特征，属于m3亚型。
The M3-selective antagonist, p-fluorohexahydro-sila-difenidol was used to characterize muscarinic receptors in two vascular preparations, the rabbit ear artery with an endothelium-dependent relaxation and the bovine coronary artery with an endothelium-independent contractile response. pKBvalues were consistent with the presence of M3receptors, 7.9 and 7.5 in coronary and ear arteries, respectively. These findings confirm that muscarinic receptors of the rabbit ear artery and bovine coronary artery have similar characteristics and belong to the M3subtype.