Deficit schizophrenia: Association with serum antibodies to cytomegalovirus
Deficit schizophrenia: Association with serum antibodies to cytomegalovirus
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DOI：
10.1093/schbul/sbi054
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发表时间：
2006-04-01
影响因子：
6.6
通讯作者：
Yolken, R
中科院分区：
文献类型：
--
作者：
Dickerson, F;Kirkpatrick, B;Yolken, R
背景资料：缺陷型精神分裂症患者与非缺陷型精神分裂症患者在几个神经生物学相关因素以及家族史和出生季节等危险因素方面存在差异。暴露于人类疱疹病毒是精神分裂症的一个可能的危险因素。我们假设，将有赤字/非赤字的人类疱疹病毒血清抗体的患病率的差异。研究方法：在缺陷型（N = 88）和非缺陷型（N = 235）精神分裂症患者中，我们测定了6种已知人类疱疹病毒的IgG类抗体：单纯疱疹病毒1型，单纯疱疹病毒2型，巨细胞病毒，EB病毒，人类疱疹病毒6型和水痘带状疱疹病毒。结果：缺陷分类与巨细胞病毒血清抗体的存在相关（比值比= 2.01，p = 0.006）。在已知与巨细胞病毒血清阳性相关的阳性精神病症状和人口统计学特征协变后，以及校正多重比较后，这种相关性仍然显著。单纯疱疹病毒1型和缺陷状态之间的关联是不显着的协变后，潜在的混杂变量。没有其他人类疱疹病毒与缺陷与非缺陷分类显著相关。结论：缺陷型精神分裂症和巨细胞病毒抗体血清阳性之间的关联为缺陷型和非缺陷型精神分裂症之间的病因病理生理学差异提供了进一步的证据。
Background: Patients with deficit schizophrenia differ from nondeficit patients with schizophrenia relative to several neurobiological correlates and relative to the risk factors of family history and season of birth. Exposure to human herpesviruses is a possible risk factor for schizophrenia. We hypothesized that there would be deficit/nondeficit difference in the prevalence of serum antibodies to human herpesviruses. Methods: In deficit (N = 88) and nondeficit (N = 235) schizophrenia patients, we measured IgG class antibodies to the 6 known human herpesviruses: herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, Epstein-Barr virus, human herpes virus 6, and varicella-zoster virus. Results: Deficit categorization was associated with the presence of serum antibodies to cytomegalovirus (odds ratio = 2.01, p = .006). This association remained significant after covarying for positive psychotic symptoms and demographic features known to be associated with cytomegalovirus seropositivity and after correcting for multiple comparisons. An association between herpes simplex virus type 1 and deficit status was not significant after covarying for potentially confounding variables. No other human herpesvirus was significantly associated with deficit versus nondeficit categorization. Conclusions: The association between deficit schizophrenia and cytomegalovirus antibody seropositivity provides further evidence for differences in etiopathophysiology between deficit and nondeficit schizophrenia.